Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03426 / KIME_HUMAN
Protein Name Mevalonate kinase
Gene Name Name: MVK
Organism Homo sapiens (Human)

PRO ID PR:Q03426
DAG View
PRO Name mevalonate kinase (human)
Definition A mevalonate kinase that is encoded in the genome of human.
Short Label hMVK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03426 (MVK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T37 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T37 A37 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S227 L227 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S227 P227 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K238 T238 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]