iPTMnet Report for Q03426 (MVK)
Protein Information
| UniProt AC / UniProt ID | Q03426 / KIME_HUMAN |
| Protein Name | Mevalonate kinase |
| Gene Name | Name: MVK |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q03426 |
| PRO Name | mevalonate kinase (human) |
| Definition | A mevalonate kinase that is encoded in the genome of human. |
| Short Label | hMVK |
| Category | organism-gene |
DAG ViewQ03426 (MVK) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S45 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K90 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K179 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K220 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S227 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K345 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T37 | A37 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S227 | L227 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S227 | P227 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K238 | T238 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |
