iPTMnet Report Q03393 PTS

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q03393 / PTPS_HUMAN
Protein Name	6-pyruvoyl tetrahydrobiopterin synthase
Gene Name	Name: PTS
Organism	Homo sapiens (Human)

PRO ID	PR:Q03393 DAG View
PRO Name	6-pyruvoyl tetrahydrobiopterin synthase (human)
Definition	A 6-pyruvoyl tetrahydrobiopterin synthase that is encoded in the genome of human.
Short Label	hPTS
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q03393 (PTS) as Substrate

Q03393

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S19	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	23186163, 24275569, 18669648, ...7493990, 10531334, 20166139, 20068231
	S19	Phosphorylation	Q13237 (PRKG2)	score4	HPRD neXtProt PhosphoSitePlus Signor	20166139, 10531334, 20068231, ...7493990
	S19	Phosphorylation	Q13976 (PRKG1)	score3	PhosphoSitePlus Signor	10531334
	S21	Phosphorylation		score0	HPRD	20068231
	S23	Phosphorylation		score0	HPRD	20068231
	K29	Ubiquitination		score1	PhosphoSitePlus
	S32	Phosphorylation		score1	PhosphoSitePlus
	K38	Ubiquitination		score1	PhosphoSitePlus
	K42	Ubiquitination		score1	PhosphoSitePlus
	T58	Phosphorylation		score1	PhosphoSitePlus
	K77	Ubiquitination		score1	PhosphoSitePlus
	Y128	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
	K129	Ubiquitination		score1	PhosphoSitePlus
	K131	Ubiquitination		score1	PhosphoSitePlus
	K143	Ubiquitination		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K131	Q131	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]