Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03188 / CENPC_HUMAN
Protein Name Centromere protein C
Gene Name Name: CENPC
Synonyms:CENPC1,ICEN7;
Organism Homo sapiens (Human)

PRO ID PR:Q03188
DAG View
PRO Name centromere protein C (human)
Definition A centromere protein C that is encoded in the genome of human.
Short Label hCENPC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03188 (CENPC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   UniProt 23186163
S75 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus   UniProt 20068231
S110 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S126 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S127 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T130 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S133 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus   UniProt 19690332
S158 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
T167 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S170 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S176 Phosphorylation PhosphoSitePlus
S177 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K180 Ubiquitination PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y184 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 19690332
S225 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
T231 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S261 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T264 Phosphorylation phospho.ELM 18669648
K271 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S316 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16565220
T319 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16565220
K349 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K414 Methylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
K440 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus   UniProt 23186163
K534 Sumoylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S538 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19690332, 20068231, ...16565220
Y541 Phosphorylation PhosphoSitePlus
K579 Acetylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus   UniProt 23186163
S709 Phosphorylation PhosphoSitePlus   UniProt 21406692
S710 Phosphorylation PhosphoSitePlus   UniProt 21406692
S713 Phosphorylation PhosphoSitePlus
K721 Sumoylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
T734 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K746 Sumoylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
Y750 Phosphorylation PhosphoSitePlus
Y758 Phosphorylation PhosphoSitePlus
S763 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S773 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
K807 Ubiquitination PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
T825 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation HPRD 19007248, 19691289
S52 Phosphorylation HPRD 19691289
S55 Phosphorylation HPRD 19691289
S73 Phosphorylation HPRD 20068231
S75 Phosphorylation HPRD 19691289
S96 Phosphorylation HPRD 19691289, 20068231
S126 Phosphorylation HPRD 18669648
T130 Phosphorylation HPRD 18669648, 19691289, 20068231
S133 Phosphorylation HPRD 20068231
S158 Phosphorylation HPRD 20068231
T167 Phosphorylation HPRD 16565220
S170 Phosphorylation HPRD 16565220
S177 Phosphorylation HPRD 16565220
S225 Phosphorylation HPRD 19651622, 17081983, 20068231, ...19007248
S261 Phosphorylation HPRD 18669648
T264 Phosphorylation HPRD 18669648
S277 Phosphorylation HPRD 19007248, 19691289
S308 Phosphorylation HPRD 20068231
S311 Phosphorylation HPRD 20068231
S316 Phosphorylation HPRD 18669648, 16565220, 19664995, ...20068231, 19007248
S333 Phosphorylation HPRD 19007248, 16565220
S439 Phosphorylation HPRD 19007248, 20068231, 19691289
S520 Phosphorylation HPRD 17081983
S524 Phosphorylation HPRD 17081983
S535 Phosphorylation HPRD 19691289
S538 Phosphorylation HPRD 16565220, 19691289, 20068231, ...19007248
S600 Phosphorylation HPRD 19007248
S613 Phosphorylation HPRD 19691289
S684 Phosphorylation HPRD 19007248, 19691289
S709 Phosphorylation HPRD 19651622, 20068231
S710 Phosphorylation HPRD 19651622
T734 Phosphorylation HPRD 20068231
S763 Phosphorylation HPRD 18669648, 20068231
S773 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 * Biomuta DOID:3571 / liver cancer [ icgc ]
K84 M84 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S170 L170 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
K180 N180 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
Y184 * Biomuta DOID:363 / uterine cancer [ tcga ]
Y184 C184 Biomuta DOID:263 / kidney cancer [ cosmic ]
S189 L189 Biomuta DOID:1909 / melanoma [ tcga ]
T231 A231 Biomuta DOID:363 / uterine cancer [ tcga ]
S261 C261 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K273 Q273 Biomuta DOID:363 / uterine cancer [ tcga ]
S538 G538 Biomuta DOID:3571 / liver cancer [ icgc ]
S620 I620 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
S679 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K721 N721 Biomuta DOID:363 / uterine cancer [ tcga ]
S773 F773 Biomuta DOID:4159 / skin cancer [ icgc ]