Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03164 / KMT2A_HUMAN
Protein Name Histone-lysine N-methyltransferase 2A
Gene Name Name: KMT2A
Synonyms:ALL1,CXXC7,HRX,HTRX,MLL,MLL1,TRX1;
Organism Homo sapiens (Human)

PRO ID PR:Q03164
DAG View
PRO Name histone-lysine N-methyltransferase 2A (human)
Definition A histone-lysine N-methyltransferase 2A that is encoded in the genome of human.
Short Label hKMT2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03164 (KMT2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
R25 Methylation PhosphoSitePlus
R32 Methylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S136 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S142 Phosphorylation PhosphoSitePlus
S153 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S161 Phosphorylation PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S202 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T204 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
T337 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S351 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S504 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T506 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S516 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 4709074, 20818375
S518 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
Y531 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K623 Methylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus   UniProt 19608861
K636 Methylation PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S680 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S684 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
R701 Methylation PhosphoSitePlus
T703 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T716 Phosphorylation PhosphoSitePlus
R721 Methylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
T726 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
S828 Phosphorylation phospho.ELM 18669648
S829 Phosphorylation phospho.ELM 18669648
S831 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T833 Phosphorylation phospho.ELM 18669648
T840 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S843 Phosphorylation PhosphoSitePlus
K895 Acetylation PhosphoSitePlus
S897 Phosphorylation PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus   UniProt 20068231
K928 Acetylation PhosphoSitePlus
T972 Phosphorylation PhosphoSitePlus
T979 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus
T993 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1056 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1058 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
S1062 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
K1130 Acetylation PhosphoSitePlus   UniProt 19608861
S1220 Phosphorylation PhosphoSitePlus
K1235 Acetylation PhosphoSitePlus   UniProt 19608861
S1240 Phosphorylation PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
T1245 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
K1345 Acetylation PhosphoSitePlus
K1346 Acetylation PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
S1535 Phosphorylation PhosphoSitePlus
T1540 Phosphorylation PhosphoSitePlus
Y1576 Phosphorylation PhosphoSitePlus
Y1581 Phosphorylation PhosphoSitePlus
S1583 Phosphorylation PhosphoSitePlus
T1649 Phosphorylation PhosphoSitePlus
S1684 Phosphorylation PhosphoSitePlus
S1685 Phosphorylation PhosphoSitePlus
K1712 Ubiquitination PhosphoSitePlus
S1837 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220, 24275569, ...18220336
T1839 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1845 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220, 18220336
S1854 Phosphorylation PhosphoSitePlus
S1858 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
K1970 Ubiquitination PhosphoSitePlus
S2005 Phosphorylation PhosphoSitePlus
S2098 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T2100 Phosphorylation PhosphoSitePlus
T2103 Phosphorylation PhosphoSitePlus
S2118 Phosphorylation PhosphoSitePlus
S2121 Phosphorylation PhosphoSitePlus
T2147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2149 Phosphorylation PhosphoSitePlus
Y2150 Phosphorylation PhosphoSitePlus
S2151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
T2153 Phosphorylation PhosphoSitePlus
S2156 Phosphorylation PhosphoSitePlus
S2164 Phosphorylation PhosphoSitePlus
S2167 Phosphorylation PhosphoSitePlus
T2169 Phosphorylation PhosphoSitePlus
T2171 Phosphorylation PhosphoSitePlus
S2185 Phosphorylation PhosphoSitePlus
S2196 Phosphorylation PhosphoSitePlus
T2197 Phosphorylation PhosphoSitePlus
S2198 Phosphorylation PhosphoSitePlus
S2199 Phosphorylation PhosphoSitePlus
S2201 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2211 Phosphorylation PhosphoSitePlus
S2291 Phosphorylation PhosphoSitePlus
S2298 Phosphorylation PhosphoSitePlus
S2301 Phosphorylation PhosphoSitePlus
S2302 Phosphorylation PhosphoSitePlus
S2313 Phosphorylation PhosphoSitePlus
S2315 Phosphorylation PhosphoSitePlus
S2316 Phosphorylation PhosphoSitePlus
S2350 Phosphorylation PhosphoSitePlus
S2391 Phosphorylation PhosphoSitePlus
S2392 Phosphorylation PhosphoSitePlus
S2420 Phosphorylation PhosphoSitePlus
S2493 Phosphorylation PhosphoSitePlus
S2508 Phosphorylation PhosphoSitePlus
T2523 Phosphorylation PhosphoSitePlus
T2525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2611 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y2616 Phosphorylation PhosphoSitePlus
S2625 Phosphorylation PhosphoSitePlus
T2632 Phosphorylation PhosphoSitePlus
Y2635 Phosphorylation PhosphoSitePlus
T2652 Phosphorylation PhosphoSitePlus
K2654 Acetylation PhosphoSitePlus
K2655 Acetylation PhosphoSitePlus
S2691 Phosphorylation PhosphoSitePlus
T2724 Phosphorylation PhosphoSitePlus
S2726 Phosphorylation PhosphoSitePlus
T2728 Phosphorylation PhosphoSitePlus
T2731 Phosphorylation PhosphoSitePlus
T2733 Phosphorylation PhosphoSitePlus
T2734 Phosphorylation PhosphoSitePlus
K2746 Acetylation PhosphoSitePlus
T2750 Phosphorylation PhosphoSitePlus
K2754 Acetylation PhosphoSitePlus
K2775 Acetylation PhosphoSitePlus
K2790 Ubiquitination PhosphoSitePlus
T2791 Phosphorylation PhosphoSitePlus
S2796 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2814 Phosphorylation PhosphoSitePlus
K2818 Acetylation PhosphoSitePlus
S2866 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S2872 Phosphorylation PhosphoSitePlus
S2885 Phosphorylation PhosphoSitePlus
S2909 Phosphorylation PhosphoSitePlus
S2938 Phosphorylation PhosphoSitePlus
T2940 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S2955 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K2958 Acetylation PhosphoSitePlus
S3026 Phosphorylation PhosphoSitePlus
S3027 Phosphorylation PhosphoSitePlus
T3028 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3036 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
T3038 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3050 Phosphorylation PhosphoSitePlus
S3053 Phosphorylation PhosphoSitePlus
S3057 Phosphorylation phospho.ELM 18669648
T3067 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3208 Phosphorylation PhosphoSitePlus
T3210 Phosphorylation PhosphoSitePlus
T3213 Phosphorylation PhosphoSitePlus
S3216 Phosphorylation PhosphoSitePlus
K3219 Acetylation PhosphoSitePlus
T3281 Phosphorylation PhosphoSitePlus
K3287 Ubiquitination PhosphoSitePlus
T3372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S3502 Phosphorylation PhosphoSitePlus
S3508 Phosphorylation PhosphoSitePlus
T3510 Phosphorylation PhosphoSitePlus
S3511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163
S3515 Phosphorylation PhosphoSitePlus   UniProt 19690332
S3517 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3518 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3520 Phosphorylation PhosphoSitePlus
S3521 Phosphorylation PhosphoSitePlus
S3525 Phosphorylation PhosphoSitePlus
S3527 Phosphorylation PhosphoSitePlus   UniProt 23186163
K3535 Acetylation PhosphoSitePlus
K3549 Acetylation PhosphoSitePlus
K3553 Acetylation PhosphoSitePlus
T3634 Phosphorylation PhosphoSitePlus
S3643 Phosphorylation PhosphoSitePlus
S3644 Phosphorylation PhosphoSitePlus
K3696 Ubiquitination PhosphoSitePlus
K3707 Ubiquitination PhosphoSitePlus
K3749 Acetylation PhosphoSitePlus
K3749 Ubiquitination PhosphoSitePlus
K3784 Ubiquitination PhosphoSitePlus
K3804 Methylation PhosphoSitePlus
K3804 Ubiquitination PhosphoSitePlus
S3827 Phosphorylation PhosphoSitePlus
S3836 Phosphorylation PhosphoSitePlus
Y3914 Phosphorylation PhosphoSitePlus
K3945 Ubiquitination PhosphoSitePlus
K3954 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 18669648
S153 Phosphorylation HPRD 18669648, 20068231, 18452278
S161 Phosphorylation HPRD 19651622
S167 Phosphorylation HPRD 19651622
S197 Phosphorylation HPRD 18669648, 20068231
S202 Phosphorylation HPRD 18669648
T268 Phosphorylation HPRD 20068231
S279 Phosphorylation HPRD 19691289, 20068231, 17924679
S283 Phosphorylation HPRD 20068231
T337 Phosphorylation HPRD 19007248, 19691289, 20068231, ...17081983
S418 Phosphorylation HPRD 20068231
T424 Phosphorylation HPRD 20068231
S504 Phosphorylation HPRD 18669648
T506 Phosphorylation HPRD 18669648
S518 Phosphorylation HPRD 18669648, 20068231, 18452278
S680 Phosphorylation HPRD 18669648, 20068231
S684 Phosphorylation HPRD 20068231
S742 Phosphorylation HPRD 20068231
S828 Phosphorylation HPRD 18669648
S829 Phosphorylation HPRD 18669648
S831 Phosphorylation HPRD 18669648
T833 Phosphorylation HPRD 18669648
T840 Phosphorylation HPRD 18669648
S897 Phosphorylation HPRD 20068231
S901 Phosphorylation HPRD 20068231
S926 Phosphorylation HPRD 19007248, 20068231
T972 Phosphorylation HPRD 20068231
S982 Phosphorylation HPRD 20068231
S1056 Phosphorylation HPRD 18669648
S1241 Phosphorylation HPRD 19007248
T1376 Phosphorylation HPRD 20068231
S1682 Phosphorylation HPRD 20068231
S1684 Phosphorylation HPRD 18452278
S1685 Phosphorylation HPRD 18452278
S1837 Phosphorylation HPRD 19651622, 18669648, 20068231, ...16565220
T1839 Phosphorylation HPRD 18669648
T1845 Phosphorylation HPRD 19651622, 18669648, 20068231, ...16565220
S1858 Phosphorylation HPRD 18669648, 20068231
T2094 Phosphorylation HPRD 19691289
S2098 Phosphorylation HPRD 19651622, 18669648, 19691289, ...18452278
T2147 Phosphorylation HPRD 18669648
S2151 Phosphorylation HPRD 18669648, 15302935, 19691289
T2153 Phosphorylation HPRD 19007248, 19691289
S2198 Phosphorylation HPRD 20068231
T2525 Phosphorylation HPRD 18669648, 20068231
S2691 Phosphorylation HPRD 19007248, 20068231
S2729 Phosphorylation HPRD 19007248
T2750 Phosphorylation HPRD 20068231
S2866 Phosphorylation HPRD 15302935
S2870 Phosphorylation HPRD 20068231
S2871 Phosphorylation HPRD 20068231
S2938 Phosphorylation HPRD 19691289
T2940 Phosphorylation HPRD 15302935
S2953 Phosphorylation HPRD 19691289
S2955 Phosphorylation HPRD 18669648, 19007248, 20068231, ...19691289
T3028 Phosphorylation HPRD 18669648, 20068231
S3036 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231
T3038 Phosphorylation HPRD 18669648
S3050 Phosphorylation HPRD 19413330
S3053 Phosphorylation HPRD 20068231
S3057 Phosphorylation HPRD 18669648
T3067 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S3216 Phosphorylation HPRD 20068231
T3372 Phosphorylation HPRD 18669648, 20068231
S3508 Phosphorylation HPRD 20068231
S3511 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231
S3515 Phosphorylation HPRD 19413330, 20068231
S3517 Phosphorylation HPRD 18669648, 20068231
S3518 Phosphorylation HPRD 18669648
S3525 Phosphorylation HPRD 19691289
S3527 Phosphorylation HPRD 19691289
S3644 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03164 (KMT2A) S516 Q13309 (SKP2) unknown eFIP 20818375


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S94 L94 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S153 L153 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S191 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S261 F261 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S279 F279 Biomuta DOID:4362 / cervical cancer [ tcga ]
S308 L308 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T506 A506 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S534 L534 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K623 N623 Biomuta DOID:363 / uterine cancer [ tcga ]
S680 L680 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
T703 I703 Biomuta DOID:363 / uterine cancer [ tcga ]
S728 F728 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S752 P752 Biomuta DOID:263 / kidney cancer [ tcga ]
S754 P754 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K895 R895 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S901 R901 Biomuta DOID:1612 / breast cancer [ tcga ]
T972 N972 Biomuta DOID:363 / uterine cancer [ tcga ]
S1058 * Biomuta DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1058 L1058 Biomuta DOID:1324 / lung cancer [ tcga ]
S1062 Y1062 Biomuta DOID:1909 / melanoma [ cosmic ]
S1062 P1062 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1114 L1114 Biomuta DOID:1909 / melanoma [ tcga ] DOID:1324 / lung cancer [ tcga ]
S1241 I1241 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T1245 P1245 Biomuta DOID:1612 / breast cancer [ icgc ]
S1352 N1352 Biomuta DOID:3571 / liver cancer [ icgc ]
Y1581 C1581 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
T1839 A1839 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T2100 I2100 Biomuta DOID:363 / uterine cancer [ tcga ]
S2149 G2149 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2149 R2149 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2167 N2167 Biomuta DOID:1612 / breast cancer [ tcga ]
S2350 F2350 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S2493 F2493 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y2616 C2616 Biomuta DOID:363 / uterine cancer [ tcga ]
T2652 I2652 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2866 R2866 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2885 N2885 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
T2940 A2940 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T2940 I2940 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S3026 T3026 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S3216 Y3216 Biomuta DOID:3070 / malignant glioma [ tcga ]
T3372 S3372 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S3515 A3515 Biomuta DOID:3963 / thyroid carcinoma [ icgc, tcga ]
S3515 F3515 Biomuta DOID:3963 / thyroid carcinoma [ icgc, tcga ]