iPTMnet Report for Q03164 (KMT2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03164 / KMT2A_HUMAN
Protein Name Histone-lysine N-methyltransferase 2A
Gene Name Name: KMT2A
Synonyms:ALL1,CXXC7,HRX,HTRX,MLL,MLL1,TRX1;
Organism Homo sapiens (Human)

PRO ID PR:Q03164
DAG View
PRO Name histone-lysine N-methyltransferase 2A (human)
Definition A histone-lysine N-methyltransferase 2A that is encoded in the genome of human.
Short Label hKMT2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03164 (KMT2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
R25 Methylation PhosphoSitePlus
R32 Methylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S136 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 29997176
S142 Phosphorylation PhosphoSitePlus   UniProt 29997176
S153 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...29997176
S161 Phosphorylation PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S181 Phosphorylation IEDB   PhosphoSitePlus 27920218
S183 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S202 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T204 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
T259 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
T259 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
T337 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S351 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S504 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T506 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S516 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 4709074, 20818375
S518 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
Y531 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S540 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S540 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
T616 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
K623 Methylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus   UniProt 19608861
K636 Methylation PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S680 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S684 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
R701 Methylation PhosphoSitePlus
T703 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T716 Phosphorylation PhosphoSitePlus
R721 Methylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
T726 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
S764 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
T771 Phosphorylation PhosphoSitePlus
S775 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S777 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S778 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S781 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S783 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S828 Phosphorylation phospho.ELM 18669648
S829 Phosphorylation phospho.ELM 18669648
S831 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T833 Phosphorylation phospho.ELM 18669648
T840 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S843 Phosphorylation PhosphoSitePlus
K895 Acetylation PhosphoSitePlus
S897 Phosphorylation PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S925 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S926 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S926 Phosphorylation PhosphoSitePlus   UniProt 20068231
K928 Acetylation PhosphoSitePlus
T972 Phosphorylation PhosphoSitePlus
T979 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus
T993 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1056 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1058 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
S1062 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
K1130 Acetylation PhosphoSitePlus   UniProt 19608861
S1220 Phosphorylation PhosphoSitePlus
K1235 Acetylation PhosphoSitePlus   UniProt 19608861
S1240 Phosphorylation PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
T1245 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
S1325 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
K1345 Acetylation PhosphoSitePlus
K1346 Acetylation PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
S1535 Phosphorylation PhosphoSitePlus
T1540 Phosphorylation PhosphoSitePlus
Y1576 Phosphorylation PhosphoSitePlus
Y1581 Phosphorylation PhosphoSitePlus
S1583 Phosphorylation PhosphoSitePlus
N1601 N-Glycosylation GlyGen 29671580
T1649 Phosphorylation PhosphoSitePlus
S1684 Phosphorylation PhosphoSitePlus
S1685 Phosphorylation PhosphoSitePlus
K1712 Ubiquitination PhosphoSitePlus
S1837 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220, 24275569, ...18220336
T1839 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1845 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220, 18220336
S1854 Phosphorylation PhosphoSitePlus
S1858 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S1858 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
C1950 Methylation IEDB 31844290
K1970 Ubiquitination PhosphoSitePlus
S2005 Phosphorylation PhosphoSitePlus
S2098 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T2100 Phosphorylation PhosphoSitePlus
T2103 Phosphorylation PhosphoSitePlus
S2118 Phosphorylation PhosphoSitePlus
S2121 Phosphorylation PhosphoSitePlus
T2147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2149 Phosphorylation PhosphoSitePlus
Y2150 Phosphorylation PhosphoSitePlus
S2151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
T2153 Phosphorylation PhosphoSitePlus
S2156 Phosphorylation PhosphoSitePlus
S2164 Phosphorylation PhosphoSitePlus
S2167 Phosphorylation PhosphoSitePlus
T2169 Phosphorylation PhosphoSitePlus
T2171 Phosphorylation PhosphoSitePlus
S2185 Phosphorylation PhosphoSitePlus
S2196 Phosphorylation PhosphoSitePlus
T2197 Phosphorylation PhosphoSitePlus
S2198 Phosphorylation PhosphoSitePlus
S2199 Phosphorylation PhosphoSitePlus
S2201 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2211 Phosphorylation PhosphoSitePlus
S2291 Phosphorylation PhosphoSitePlus
S2298 Phosphorylation PhosphoSitePlus
S2301 Phosphorylation PhosphoSitePlus
S2302 Phosphorylation PhosphoSitePlus
S2313 Phosphorylation PhosphoSitePlus
S2315 Phosphorylation PhosphoSitePlus
S2316 Phosphorylation PhosphoSitePlus
S2340 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S2350 Phosphorylation PhosphoSitePlus
S2391 Phosphorylation PhosphoSitePlus
S2392 Phosphorylation PhosphoSitePlus
S2420 Phosphorylation PhosphoSitePlus
S2493 Phosphorylation PhosphoSitePlus
S2508 Phosphorylation PhosphoSitePlus
T2523 Phosphorylation PhosphoSitePlus
T2525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2611 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y2616 Phosphorylation PhosphoSitePlus
S2625 Phosphorylation PhosphoSitePlus
T2632 Phosphorylation PhosphoSitePlus
Y2635 Phosphorylation PhosphoSitePlus
T2652 Phosphorylation PhosphoSitePlus
K2654 Acetylation PhosphoSitePlus
K2655 Acetylation PhosphoSitePlus
S2691 Phosphorylation PhosphoSitePlus
T2724 Phosphorylation PhosphoSitePlus
S2726 Phosphorylation PhosphoSitePlus
T2728 Phosphorylation PhosphoSitePlus
T2731 Phosphorylation PhosphoSitePlus
T2733 Phosphorylation PhosphoSitePlus
T2734 Phosphorylation PhosphoSitePlus
K2746 Acetylation PhosphoSitePlus
T2750 Phosphorylation PhosphoSitePlus
K2754 Acetylation PhosphoSitePlus
K2775 Acetylation PhosphoSitePlus
K2790 Ubiquitination PhosphoSitePlus
T2791 Phosphorylation PhosphoSitePlus
S2796 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2814 Phosphorylation PhosphoSitePlus
K2818 Acetylation PhosphoSitePlus
S2866 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S2872 Phosphorylation PhosphoSitePlus
S2885 Phosphorylation PhosphoSitePlus
S2909 Phosphorylation PhosphoSitePlus
S2938 Phosphorylation PhosphoSitePlus
T2940 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S2955 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K2958 Acetylation PhosphoSitePlus
S3026 Phosphorylation PhosphoSitePlus
S3027 Phosphorylation PhosphoSitePlus
T3028 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3036 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
T3038 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3050 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S3050 Phosphorylation PhosphoSitePlus
T3051 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S3053 Phosphorylation PhosphoSitePlus
S3057 Phosphorylation phospho.ELM 18669648
S3060 O-Glycosylation GlyGen 32574038
T3067 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3208 Phosphorylation PhosphoSitePlus
T3210 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
T3210 Phosphorylation PhosphoSitePlus
T3213 Phosphorylation PhosphoSitePlus
S3216 Phosphorylation PhosphoSitePlus
K3219 Acetylation PhosphoSitePlus
S3238 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S3241 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S3267 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
S3273 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
T3281 Phosphorylation PhosphoSitePlus
K3287 Ubiquitination PhosphoSitePlus
T3353 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34725712, 34019948, 21740066, 29351928, 35132862, 20305658, 32119511, 35289036, 35254053
T3372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S3502 Phosphorylation PhosphoSitePlus
S3508 Phosphorylation PhosphoSitePlus
T3510 Phosphorylation PhosphoSitePlus
S3511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
S3515 Phosphorylation PhosphoSitePlus   UniProt 19690332
S3517 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3518 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3520 Phosphorylation PhosphoSitePlus
S3521 Phosphorylation PhosphoSitePlus
S3525 Phosphorylation PhosphoSitePlus
S3527 Phosphorylation PhosphoSitePlus   UniProt 23186163
K3535 Acetylation PhosphoSitePlus
K3549 Acetylation PhosphoSitePlus
K3553 Acetylation PhosphoSitePlus
T3634 Phosphorylation PhosphoSitePlus
S3643 Phosphorylation PhosphoSitePlus
S3644 Phosphorylation PhosphoSitePlus
K3696 Ubiquitination PhosphoSitePlus
K3707 Ubiquitination PhosphoSitePlus
K3749 Acetylation PhosphoSitePlus
K3749 Ubiquitination PhosphoSitePlus
K3784 Ubiquitination PhosphoSitePlus
K3804 Methylation PhosphoSitePlus
K3804 Ubiquitination PhosphoSitePlus
S3827 Phosphorylation PhosphoSitePlus
S3836 Phosphorylation PhosphoSitePlus
C3882 Methylation Q03164 (KMT2A) UniProt 24235145
Y3914 Phosphorylation PhosphoSitePlus
K3945 Ubiquitination PhosphoSitePlus
K3954 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 18669648
S153 Phosphorylation HPRD 18669648, 20068231, 18452278
S161 Phosphorylation HPRD 19651622
S167 Phosphorylation HPRD 19651622
S197 Phosphorylation HPRD 18669648, 20068231
S202 Phosphorylation HPRD 18669648
T268 Phosphorylation HPRD 20068231
S279 Phosphorylation HPRD 19691289, 20068231, 17924679
S283 Phosphorylation HPRD 20068231
T337 Phosphorylation HPRD 19007248, 19691289, 20068231, ...17081983
S418 Phosphorylation HPRD 20068231
T424 Phosphorylation HPRD 20068231
S504 Phosphorylation HPRD 18669648
T506 Phosphorylation HPRD 18669648
S518 Phosphorylation HPRD 18669648, 20068231, 18452278
S680 Phosphorylation HPRD 18669648, 20068231
S684 Phosphorylation HPRD 20068231
S742 Phosphorylation HPRD 20068231
S828 Phosphorylation HPRD 18669648
S829 Phosphorylation HPRD 18669648
S831 Phosphorylation HPRD 18669648
T833 Phosphorylation HPRD 18669648
T840 Phosphorylation HPRD 18669648
S897 Phosphorylation HPRD 20068231
S901 Phosphorylation HPRD 20068231
S926 Phosphorylation HPRD 19007248, 20068231
T972 Phosphorylation HPRD 20068231
S982 Phosphorylation HPRD 20068231
S1056 Phosphorylation HPRD 18669648
S1241 Phosphorylation HPRD 19007248
T1376 Phosphorylation HPRD 20068231
N1601 N-Glycosylation PRO 29671580
S1682 Phosphorylation HPRD 20068231
S1684 Phosphorylation HPRD 18452278
S1685 Phosphorylation HPRD 18452278
S1837 Phosphorylation HPRD 19651622, 18669648, 20068231, ...16565220
T1839 Phosphorylation HPRD 18669648
T1845 Phosphorylation HPRD 19651622, 18669648, 20068231, ...16565220
S1858 Phosphorylation HPRD 18669648, 20068231
T2094 Phosphorylation HPRD 19691289
S2098 Phosphorylation HPRD 19651622, 18669648, 19691289, ...18452278
T2147 Phosphorylation HPRD 18669648
S2151 Phosphorylation HPRD 18669648, 15302935, 19691289
T2153 Phosphorylation HPRD 19007248, 19691289
S2198 Phosphorylation HPRD 20068231
T2525 Phosphorylation HPRD 18669648, 20068231
S2691 Phosphorylation HPRD 19007248, 20068231
S2729 Phosphorylation HPRD 19007248
T2750 Phosphorylation HPRD 20068231
S2866 Phosphorylation HPRD 15302935
S2870 Phosphorylation HPRD 20068231
S2871 Phosphorylation HPRD 20068231
S2938 Phosphorylation HPRD 19691289
T2940 Phosphorylation HPRD 15302935
S2953 Phosphorylation HPRD 19691289
S2955 Phosphorylation HPRD 18669648, 19007248, 20068231, ...19691289
T3028 Phosphorylation HPRD 18669648, 20068231
S3036 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231
T3038 Phosphorylation HPRD 18669648
S3050 Phosphorylation HPRD 19413330
S3053 Phosphorylation HPRD 20068231
S3057 Phosphorylation HPRD 18669648
T3067 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S3216 Phosphorylation HPRD 20068231
T3372 Phosphorylation HPRD 18669648, 20068231
S3508 Phosphorylation HPRD 20068231
S3511 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231
S3515 Phosphorylation HPRD 19413330, 20068231
S3517 Phosphorylation HPRD 18669648, 20068231
S3518 Phosphorylation HPRD 18669648
S3525 Phosphorylation HPRD 19691289
S3527 Phosphorylation HPRD 19691289
S3644 Phosphorylation HPRD 20068231


Q03164 (KMT2A) as PTM Enzyme



Substrate Site Score Source PMID
Q03164 (KMT2A) C3882 UniProt 24235145


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03164 (KMT2A) S516 Q13309 (SKP2) unknown eFIP 20818375


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S92 L92 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S92 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S94 L94 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S153 L153 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S161 I161 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S167 * Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S183 F183 Biomuta DOID:4159 / skin cancer [ cosmic ]
S191 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S197 F197 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T259 I259 Biomuta DOID:1324 / lung cancer [ cosmic ]
S261 F261 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S279 F279 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S308 L308 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S364 L364 Biomuta DOID:4159 / skin cancer [ cosmic ]
S418 C418 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T506 I506 Biomuta DOID:4159 / skin cancer [ cosmic ]
S534 L534 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S537 N537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S540 Y540 Biomuta DOID:363 / uterine cancer [ cosmic ]
K623 N623 Biomuta DOID:363 / uterine cancer [ icgc ]
Y631 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S670 C670 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S680 L680 Biomuta DOID:11615 / penile cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S694 R694 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T703 I703 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R721 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R721 Q721 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T726 A726 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S728 F728 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S754 Y754 Biomuta DOID:1324 / lung cancer [ cosmic ]
S754 P754 Biomuta DOID:1324 / lung cancer [ cosmic ]
S764 N764 Biomuta DOID:4159 / skin cancer [ cosmic ]
S775 F775 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S777 F777 Biomuta DOID:1324 / lung cancer [ cosmic ]
S777 C777 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S778 F778 Biomuta DOID:4159 / skin cancer [ cosmic ]
S783 F783 Biomuta DOID:1324 / lung cancer [ cosmic ]
S783 Y783 Biomuta DOID:1612 / breast cancer [ cosmic ]
S828 L828 Biomuta DOID:4159 / skin cancer [ cosmic ]
K895 R895 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S912 F912 Biomuta DOID:4159 / skin cancer [ cosmic ]
S925 Y925 Biomuta DOID:263 / kidney cancer [ cosmic ]
T972 N972 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T979 S979 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S982 F982 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S992 F992 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S1004 F1004 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S1058 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1058 L1058 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1062 F1062 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1062 Y1062 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1062 P1062 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1114 L1114 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1220 F1220 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1220 Y1220 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1235 T1235 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S1241 I1241 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1245 P1245 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1325 N1325 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
T1376 S1376 Biomuta [ cosmic ]
K1517 N1517 Biomuta DOID:184 / bone cancer [ cosmic ]
Y1581 C1581 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S1685 F1685 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1712 N1712 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1839 A1839 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
T1845 I1845 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2100 I2100 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2149 G2149 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2149 R2149 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2156 F2156 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2167 N2167 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S2198 Y2198 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2198 F2198 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S2201 L2201 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2302 F2302 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2350 F2350 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2350 A2350 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2391 P2391 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2392 P2392 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S2493 F2493 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2508 F2508 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y2616 C2616 Biomuta DOID:363 / uterine cancer [ icgc ]
Y2616 H2616 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2632 I2632 Biomuta DOID:1319 / brain cancer [ cosmic ]
T2652 A2652 Biomuta DOID:1612 / breast cancer [ cosmic ]
T2652 I2652 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T2652 S2652 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2728 A2728 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2734 I2734 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2734 K2734 Biomuta DOID:1612 / breast cancer [ cosmic ]
T2750 I2750 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2796 F2796 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2866 R2866 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2871 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2885 N2885 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T2940 A2940 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T2940 I2940 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S2953 L2953 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K2958 T2958 Biomuta DOID:2174 / ocular cancer [ cosmic ]
K2958 N2958 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3027 G3027 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S3036 Y3036 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S3036 F3036 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3216 Y3216 Biomuta DOID:1319 / brain cancer [ icgc ]
S3241 L3241 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3273 L3273 Biomuta DOID:263 / kidney cancer [ cosmic ]
T3372 S3372 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T3510 A3510 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3515 A3515 Biomuta DOID:1781 / thyroid cancer [ icgc ]
S3515 F3515 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S3827 C3827 Biomuta DOID:4606 / bile duct cancer [ cosmic ]