iPTMnet Report for Q03135 (CAV1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03135 / CAV1_HUMAN
Protein Name Caveolin-1
Gene Name Name: CAV1
Synonyms:CAV;
Organism Homo sapiens (Human)

PRO ID PR:Q03135
DAG View
PRO Name caveolin-1 (human)
Definition A caveolin-1 that is encoded in the genome of human.
Short Label hCAV1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03135 (CAV1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 15219854, 22814378, 20068231, ...19369195
S2 Phosphorylation PhosphoSitePlus
K5 Acetylation PhosphoSitePlus   UniProt 19608861
K5 Ubiquitination PhosphoSitePlus   UniProt 23335559
Y6 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 8632005, 15219854, ...15951569, 24632723, 20068231
S9 Phosphorylation PhosphoSitePlus
Y14 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11339833, 22505999, 12036959, ...33089394, 29340103, 17654701, 28351945, 12531427, 24364863, 17012756, 24755228, 12372346, 17121865, 18789131, 28283950, 25148256, 32440845, 28899725, 20140957, 29301501, 15692148, 21828338, 18237807, 16678999, 26919102, 23091071, 16325778, 27170175, 23469926, 24632723, 21382479, 21339325, 16568240, 29221162, 27773804, 32152405, 25672415, 20610538, 17392516, 31803361, 18176934, 14992595, 11751885, 16388599, 24467203, 25645930, 11075810, 32458278, 25005359, 22128235, 15748889, 17706093, 31113938, 18347068, 22323292, 22596063, 11451957, 23700321, 33050149, 28760776, 29118431, 16113676, 12925753, 31379509, 16943184, 29237817, 12135605, 18353778, 27376435, 25319010, 20948305, 15466865, 17979878, 35413643, 33928090, 17955336, 22433870, 8632005, 29326556, 17190831, 17868074, 23333462, 16332692, 28592633, 24131997, 11805080, 21152401, 18318117, 24427291, 12921535, 25980494, 18922892, 18083107, 29563255
Y14 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus 11805080, 12531427
Y14 Phosphorylation P06241 (FYN) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15466865, 12921535
Y14 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 15466865, 8632005, 24427291, ...12921535, 11451957, 11075810
T15 Phosphorylation PhosphoSitePlus
Y25 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8632005, 15504032, 24632723, ...15951569
K26 Sumoylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus   UniProt 23335559
K30 Ubiquitination PhosphoSitePlus   UniProt 23335559
S37 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15219854, 18669648, 24275569
K39 Ubiquitination PhosphoSitePlus   UniProt 23335559, 28593998
Y42 Phosphorylation PhosphoSitePlus   RLIMS-P 24632723
T46 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus   UniProt 23335559
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus   UniProt 23335559
K65 Ubiquitination PhosphoSitePlus
S80 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 15692148, 11078729
S88 Phosphorylation phospho.ELM 8058322
S168 Phosphorylation phospho.ELM 11078729
K176 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation HPRD 17016520, 15951569, 17389395, ...18707149
Y14 Phosphorylation HPRD   PRO 17016520, 8632005, 18578522, ...17389395, 18789131, 18707149
Y14 Phosphorylation P12931 (SRC) HPRD 17016520, 8632005, 18578522, ...17389395, 18707149
Y25 Phosphorylation HPRD 17016520, 18707149
S37 Phosphorylation HPRD 18578522, 17081983, 19007248, ...19691289, 18669648, 20166139, 20068231
Y42 Phosphorylation HPRD 17016520
S80 Phosphorylation HPRD 11078729
S88 Phosphorylation HPRD 8058322
S88 Phosphorylation P19784 (CSNK2A2) HPRD 8058322
S88 Phosphorylation P68400 (CSNK2A1) HPRD 8058322
S168 Phosphorylation HPRD 11078729


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027212 (hCAV1/iso:1/Phos:1) pY14 PRO 18789131


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P56373 (P2RX3) T388 Q03135 (CAV1) increased_association eFIP 24755854
Phosphorylation Q03135 (CAV1) Y14 Q03135 (CAV1) unknown eFIP 22433870
Phosphorylation Q03135 (CAV1) Y14 P60953 (CDC42) unknown eFIP 21828338
Phosphorylation Q03135 (CAV1) Y14 P29474 (NOS3) increased_association eFIP 22323292
Phosphorylation Q03135 (CAV1) Y14 Q01860 (POU5F1) inhibited_association eFIP 29986880
Phosphorylation Q03135 (CAV1) Y14 P08183 (ABCB1) decreased_association eFIP 31113938
Phosphorylation Q03135 (CAV1) Y14 P12931 (SRC) unknown eFIP 24131997
Phosphorylation Q03135 (CAV1) Y14 P41240 (CSK) unknown eFIP 24632723
Phosphorylation Q03135 (CAV1) Y14 P03372 (ESR1) inhibited_association eFIP 20610538
Phosphorylation Q03135 (CAV1) Y14 Q06124 (PTPN11) unknown eFIP 24632723
Phosphorylation Q03135 (CAV1) Y14 Q06124 (PTPN11) unknown eFIP 25672415
Phosphorylation Q03135 (CAV1) Y14 P17987 (TCP1) unknown eFIP 16568240
Phosphorylation Q03135 (CAV1) Y14 Q02763 (TEK) unknown eFIP 28760776
Phosphorylation Q03135 (CAV1) Y14 P35968 (KDR) unknown eFIP 12529448
Phosphorylation Q03135 (CAV1) Y14 P55957 (BID) unknown eFIP 21382479


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P41134-1 (hID1/iso:ID-A) Interaction PR:Q03135 (hCAV1) PRO 17855368
PR:P41139-1 (mID4/iso:1) Interaction PR:Q03135 (hCAV1) PRO 15280210


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T15 A15 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S88 T88 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]