iPTMnet Report for Q03112 (MECOM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03112 / MECOM_HUMAN
Protein Name Histone-lysine N-methyltransferase MECOM
Gene Name Name: MECOM
Synonyms:EVI1;
Organism Homo sapiens (Human)

PRO ID PR:Q03112
DAG View
PRO Name histone-lysine N-methyltransferase MECOM (human)
Definition A histone-lysine N-methyltransferase MECOM that is encoded in the genome of human.
Short Label hMECOM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03112 (MECOM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K190 Sumoylation PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K303 Sumoylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K364 Sumoylation PhosphoSitePlus
K374 Sumoylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
T530 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
K555 Sumoylation PhosphoSitePlus
K622 Sumoylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   UniProt 23186163
S631 Phosphorylation IEDB 35494241
K635 Sumoylation PhosphoSitePlus
K685 Sumoylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K721 Sumoylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus   UniProt 23186163
K735 Sumoylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
K752 Acetylation PhosphoSitePlus
K752 Sumoylation PhosphoSitePlus
T755 Phosphorylation PhosphoSitePlus
K787 Sumoylation PhosphoSitePlus
K800 Acetylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
K835 Sumoylation PhosphoSitePlus
T837 Phosphorylation PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K877 Sumoylation PhosphoSitePlus
T935 Phosphorylation PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
K970 Methylation PhosphoSitePlus
S997 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
K1018 Sumoylation PhosphoSitePlus
S1033 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1039 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K1053 Sumoylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
K1127 Sumoylation PhosphoSitePlus
K1132 Sumoylation PhosphoSitePlus
S1136 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation PhosphoSitePlus
K1149 Sumoylation PhosphoSitePlus
K1152 Sumoylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
T1168 Phosphorylation PhosphoSitePlus
K1184 Acetylation PhosphoSitePlus
K1184 Sumoylation PhosphoSitePlus
Y1188 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S854 Phosphorylation HPRD 17525332
S858 Phosphorylation HPRD 17525332
S860 Phosphorylation HPRD 19651622, 17525332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y64 Phosphorylation HPRD   PhosphoSitePlus 18452278
K99 Sumoylation PhosphoSitePlus
K190 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K66 Sumoylation PhosphoSitePlus
K202 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K138 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
K99 Sumoylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K202 N202 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S252 C252 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S361 L361 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S384 F384 Biomuta DOID:4159 / skin cancer [ cosmic ]
S384 Y384 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T417 R417 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T417 M417 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S631 L631 Biomuta DOID:4159 / skin cancer [ cosmic ]
S717 L717 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S717 P717 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S726 L726 Biomuta DOID:3571 / liver cancer [ cosmic ]
T755 I755 Biomuta DOID:4159 / skin cancer [ cosmic ]
K787 Q787 Biomuta DOID:1324 / lung cancer [ cosmic ]
K800 R800 Biomuta DOID:1324 / lung cancer [ cosmic ]
K800 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S860 P860 Biomuta [ cosmic ]
S1006 F1006 Biomuta [ cosmic ]
S1039 P1039 Biomuta [ cosmic ]
S1064 L1064 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1136 F1136 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1147 N1147 Biomuta [ cosmic ]
S1165 F1165 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1184 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]