iPTMnet Report for Q03111 (MLLT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03111 / ENL_HUMAN
Protein Name Protein ENL
Gene Name Name: MLLT1
Synonyms:ENL,LTG19,YEATS1;
Organism Homo sapiens (Human)

PRO ID PR:Q03111
DAG View
PRO Name protein ENL (human)
Definition A protein ENL that is encoded in the genome of human.
Short Label hMLLT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03111 (MLLT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
C5 Methylation IEDB 31844290
C99 Methylation IEDB 31844290
K121 Ubiquitination PhosphoSitePlus
S155 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Y158 Phosphorylation HPRD   PhosphoSitePlus 20068231
T163 Phosphorylation HPRD   PhosphoSitePlus 20068231
S167 Phosphorylation HPRD   PhosphoSitePlus 20068231
S170 Phosphorylation HPRD   PhosphoSitePlus 20068231
S209 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
K240 Sumoylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K262 Sumoylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
S267 Phosphorylation HPRD   PhosphoSitePlus 20068231
S283 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T289 Phosphorylation HPRD   PhosphoSitePlus 20068231
S292 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 19369195, ...19664995, 19651622, 18707149, 20068231, 17924679
S296 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18691976, 17081983, ...20068231
K298 Acetylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
T314 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18691976
S320 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
K327 Acetylation PhosphoSitePlus
S334 O-Glycosylation GlyGen 30059200
K342 Sumoylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S359 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231, ...18452278
S361 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231, ...18452278
S366 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983
S394 Phosphorylation Q13315 (ATM) PhosphoSitePlus 25921070
S398 Phosphorylation Q13315 (ATM) PhosphoSitePlus 25921070
S404 Phosphorylation HPRD   PhosphoSitePlus 18691976
S411 Phosphorylation PhosphoSitePlus
S414 Phosphorylation HPRD   PhosphoSitePlus 18691976
S419 Phosphorylation HPRD   PhosphoSitePlus 18691976
S420 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18452278
S421 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18452278
S435 Phosphorylation HPRD 17081983
S438 Phosphorylation HPRD   PhosphoSitePlus 17081983, 18452278
S440 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18452278
S442 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S444 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18452278
S447 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18452278
S450 Phosphorylation HPRD 17081983
S451 Phosphorylation HPRD   phospho.ELM 17081983
S454 Phosphorylation HPRD 17081983
S468 Phosphorylation HPRD 17081983
K469 Acetylation PhosphoSitePlus
S475 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S478 Phosphorylation HPRD   PhosphoSitePlus 17081983
S480 Phosphorylation HPRD   PhosphoSitePlus 17081983
T490 Phosphorylation PhosphoSitePlus
Y491 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C5 Y5 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C99 Y99 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C99 F99 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K121 R121 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S170 A170 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S284 I284 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T289 A289 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S292 P292 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S310 N310 Biomuta DOID:4362 / cervical cancer [ icgc ]
S315 L315 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S323 F323 Biomuta DOID:3571 / liver cancer [ cosmic ]
S325 P325 Biomuta DOID:363 / uterine cancer [ icgc ]
S325 T325 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S325 L325 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K327 N327 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S359 A359 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S366 F366 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S394 F394 Biomuta DOID:4159 / skin cancer [ cosmic ]
S421 L421 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S435 C435 Biomuta DOID:1612 / breast cancer [ icgc ]
S451 P451 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S451 F451 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S454 N454 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S480 G480 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
Y491 H491 Biomuta DOID:9256 / colorectal cancer [ cosmic ]