Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02952 / AKA12_HUMAN
Protein Name A-kinase anchor protein 12
Gene Name Name: AKAP12
Synonyms:AKAP250;
Organism Homo sapiens (Human)

PRO ID PR:Q02952
DAG View
PRO Name A-kinase anchor protein 12 (human)
Definition An A-kinase anchor protein 12 that is encoded in the genome of human.
Short Label hAKAP12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02952 (AKAP12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805, 25807930, 20213681
T7 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus   UniProt 21406692
S96 Phosphorylation PhosphoSitePlus   UniProt 21406692
S120 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K122 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus   UniProt 24275569
K177 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
K228 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S253 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K279 Ubiquitination PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T285 Phosphorylation PhosphoSitePlus
S286 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus 22028470, 17287340, 17081983
T289 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y374 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus   UniProt 21406692
S386 Phosphorylation PhosphoSitePlus
S388 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 27683220
S392 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
T469 Phosphorylation PhosphoSitePlus
C470 S-Nitrosylation dbSNO 26338901
S472 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
K491 Ubiquitination PhosphoSitePlus
S505 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 27683220
S514 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
K526 Acetylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
R537 Methylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus   UniProt 21406692
S566 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
S598 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 24275569
K602 Ubiquitination PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
S612 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569
K614 Acetylation PhosphoSitePlus
K615 Acetylation PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
S627 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 14657015, ...24275569, 17287340
S629 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163, 17081983
K639 Ubiquitination PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus   UniProt 21406692
T646 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
T649 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
S696 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   UniProt 14657015, 24275569
S697 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 14657015, 24275569
S698 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 14657015, 17081983, 24275569
S732 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 27683220
S749 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus   UniProt 24275569
K763 Ubiquitination PhosphoSitePlus
T767 Phosphorylation P06493 (CDK1) PhosphoSitePlus 23063527
K771 Acetylation PhosphoSitePlus
S772 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 14657015
K775 Acetylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
T793 Phosphorylation PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
K800 Ubiquitination PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
Y852 Phosphorylation PhosphoSitePlus
K859 Ubiquitination PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
S887 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 27683220
T904 Phosphorylation PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
T972 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus
T1039 Phosphorylation PhosphoSitePlus
K1049 Ubiquitination PhosphoSitePlus
K1051 Sumoylation PhosphoSitePlus
K1051 Ubiquitination PhosphoSitePlus
S1054 Phosphorylation PhosphoSitePlus
K1087 Acetylation PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
K1088 Acetylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
T1116 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
T1127 Phosphorylation PhosphoSitePlus
C1139 S-Nitrosylation dbSNO 26338901
S1226 Phosphorylation PhosphoSitePlus
K1234 Ubiquitination PhosphoSitePlus
T1242 Phosphorylation PhosphoSitePlus
T1246 Phosphorylation PhosphoSitePlus
S1251 Phosphorylation PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
S1259 Phosphorylation PhosphoSitePlus
K1260 Ubiquitination PhosphoSitePlus
T1264 Phosphorylation PhosphoSitePlus
Y1270 Phosphorylation PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
S1287 Phosphorylation PhosphoSitePlus
C1314 S-Nitrosylation dbSNO 26338901
K1316 Ubiquitination PhosphoSitePlus
S1324 Phosphorylation PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340
S1390 Phosphorylation PhosphoSitePlus
S1391 Phosphorylation PhosphoSitePlus
S1395 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 17081983, 24275569
S1415 Phosphorylation PhosphoSitePlus
K1456 Ubiquitination PhosphoSitePlus
C1479 S-Nitrosylation dbSNO 26338901
T1484 Phosphorylation PhosphoSitePlus
K1493 Acetylation PhosphoSitePlus
K1493 Ubiquitination PhosphoSitePlus
S1497 Phosphorylation PhosphoSitePlus
S1498 Phosphorylation PhosphoSitePlus
S1512 Phosphorylation PhosphoSitePlus
C1521 S-Nitrosylation dbSNO 26338901
K1548 Ubiquitination PhosphoSitePlus
T1564 Phosphorylation PhosphoSitePlus
K1584 Ubiquitination PhosphoSitePlus
S1587 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
T1594 Phosphorylation PhosphoSitePlus
S1628 Phosphorylation PhosphoSitePlus
S1631 Phosphorylation PhosphoSitePlus
S1635 Phosphorylation PhosphoSitePlus
S1663 Phosphorylation PhosphoSitePlus
S1674 Phosphorylation PhosphoSitePlus
K1690 Ubiquitination PhosphoSitePlus
S1691 Phosphorylation PhosphoSitePlus
K1700 Ubiquitination PhosphoSitePlus
S1712 Phosphorylation PhosphoSitePlus
T1717 Phosphorylation PhosphoSitePlus
S1720 Phosphorylation PhosphoSitePlus
T1724 Phosphorylation PhosphoSitePlus
K1725 Ubiquitination PhosphoSitePlus
S1727 Phosphorylation PhosphoSitePlus
K1750 Ubiquitination PhosphoSitePlus
T1760 Phosphorylation PhosphoSitePlus
K1769 Ubiquitination PhosphoSitePlus
S1774 Phosphorylation PhosphoSitePlus
K1776 Ubiquitination PhosphoSitePlus
S1777 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S227 Phosphorylation HPRD 19651622
S253 Phosphorylation HPRD 17287340
S280 Phosphorylation HPRD 18578522, 17081983
S283 Phosphorylation HPRD 19413330, 18578522, 17287340, ...17081983, 19664994, 19664995, 19415658
T285 Phosphorylation HPRD 17322306, 19413330, 18578522, ...19415658
S286 Phosphorylation HPRD 19413330, 17287340, 18767875, ...19664995, 18452278, 17322306, 18707149, 19415658
T289 Phosphorylation HPRD 19413330, 18767875, 19664995
T311 Phosphorylation HPRD 17081983
S312 Phosphorylation HPRD 17081983
Y374 Phosphorylation HPRD 17081983
S381 Phosphorylation HPRD 19413330, 19651622, 19664994
S388 Phosphorylation HPRD 19413330, 17525332
S483 Phosphorylation HPRD 18510355, 19413330, 19664994, ...19415658
S505 Phosphorylation HPRD 17525332
S554 Phosphorylation HPRD 18510355, 19413330
S557 Phosphorylation HPRD 19413330
S565 Phosphorylation HPRD 17081983
S566 Phosphorylation HPRD 19413330, 17081983
S568 Phosphorylation HPRD 19413330, 17081983
S569 Phosphorylation HPRD 17081983
S598 Phosphorylation HPRD 19413330, 18767875, 19664994, ...19664995, 17322306, 18707149, 18510355, 19415658
T608 Phosphorylation HPRD 17322306
S612 Phosphorylation HPRD 18212344, 18767875, 19664994, ...19664995, 17322306, 18707149
S627 Phosphorylation HPRD 17322306, 18578522, 17287340, ...18767875, 19651622, 18707149, 20166139
S629 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18707149, 18510355
S640 Phosphorylation HPRD 17081983
T642 Phosphorylation HPRD 17081983
S644 Phosphorylation HPRD 19413330, 18767875, 18452278, ...19415658, 17081983
S645 Phosphorylation HPRD 17322306, 19413330, 19415658, ...18452278
T646 Phosphorylation HPRD 19413330, 17081983
S648 Phosphorylation HPRD 18452278
T649 Phosphorylation HPRD 17081983
S651 Phosphorylation HPRD 17322306, 19413330
S696 Phosphorylation HPRD 19651622
S697 Phosphorylation HPRD 19651622, 17081983
S698 Phosphorylation HPRD 19651622, 17081983, 18452278
S732 Phosphorylation HPRD 17525332
S887 Phosphorylation HPRD 17525332
T904 Phosphorylation HPRD 17081983
S910 Phosphorylation HPRD 17081983
T1116 Phosphorylation HPRD 19413330, 19664994, 19415658
S1119 Phosphorylation HPRD 18510355
T1264 Phosphorylation HPRD 18077418
S1331 Phosphorylation HPRD 17322306, 19651622, 19664994, ...17287340, 19415658
S1390 Phosphorylation HPRD 19413330, 17081983, 19664995
S1391 Phosphorylation HPRD 19413330, 17081983, 19415658
S1395 Phosphorylation HPRD 19413330, 19664994, 19415658, ...19664995
T1760 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S129 Phosphorylation HPRD 19651622
S155 Phosphorylation HPRD 17287340
S182 Phosphorylation HPRD 18578522, 17081983
S185 Phosphorylation HPRD 19413330, 18578522, 17287340, ...17081983, 19664994, 19664995, 19415658
T187 Phosphorylation HPRD 17322306, 19413330, 18578522, ...19415658
S188 Phosphorylation HPRD 19413330, 17287340, 18767875, ...19664995, 18452278, 17322306, 18707149, 19415658
T191 Phosphorylation HPRD 19413330, 18767875, 19664995
T213 Phosphorylation HPRD 17081983
S214 Phosphorylation HPRD 17081983
Y276 Phosphorylation HPRD 17081983
S283 Phosphorylation HPRD 19413330, 19651622, 19664994
S290 Phosphorylation HPRD 19413330, 17525332
S385 Phosphorylation HPRD 18510355, 19413330, 19664994, ...19415658
S407 Phosphorylation HPRD 17525332
S456 Phosphorylation HPRD 18510355, 19413330
S459 Phosphorylation HPRD 19413330
S467 Phosphorylation HPRD 17081983
S468 Phosphorylation HPRD 19413330, 17081983
S470 Phosphorylation HPRD 19413330, 17081983
S471 Phosphorylation HPRD 17081983
S500 Phosphorylation HPRD 19413330, 18767875, 19664994, ...19664995, 17322306, 18707149, 18510355, 19415658
T510 Phosphorylation HPRD 17322306
S514 Phosphorylation HPRD 18212344, 18767875, 19664994, ...19664995, 17322306, 18707149
S529 Phosphorylation HPRD 17322306, 18578522, 17287340, ...18767875, 19651622, 18707149, 20166139
S531 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18707149, 18510355
S542 Phosphorylation HPRD 17081983
T544 Phosphorylation HPRD 17081983
S546 Phosphorylation HPRD 19413330, 18767875, 18452278, ...19415658, 17081983
S547 Phosphorylation HPRD 17322306, 19413330, 19415658, ...18452278
T548 Phosphorylation HPRD 19413330, 17081983
S550 Phosphorylation HPRD 18452278
T551 Phosphorylation HPRD 17081983
S553 Phosphorylation HPRD 17322306, 19413330
S598 Phosphorylation HPRD 19651622
S599 Phosphorylation HPRD 19651622, 17081983
S600 Phosphorylation HPRD 19651622, 17081983, 18452278
S634 Phosphorylation HPRD 17525332
S789 Phosphorylation HPRD 17525332
T806 Phosphorylation HPRD 17081983
S812 Phosphorylation HPRD 17081983
T1018 Phosphorylation HPRD 19413330, 19664994, 19415658
S1021 Phosphorylation HPRD 18510355
T1166 Phosphorylation HPRD 18077418
S1233 Phosphorylation HPRD 17322306, 19651622, 19664994, ...17287340, 19415658
S1292 Phosphorylation HPRD 19413330, 17081983, 19664995
S1293 Phosphorylation HPRD 19413330, 17081983, 19415658
S1297 Phosphorylation HPRD 19413330, 19664994, 19415658, ...19664995
T1662 Phosphorylation HPRD 19413330


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13535 (ATR) S435 Q02952 (AKAP12) increased_association eFIP 28916831


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S75 I75 Biomuta DOID:3571 / liver cancer [ icgc ]
S120 F120 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S154 I154 Biomuta DOID:1115 / sarcoma [ tcga ]
K177 T177 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K177 E177 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T184 I184 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S227 C227 Biomuta DOID:1324 / lung cancer [ cosmic ]
S248 I248 Biomuta DOID:363 / uterine cancer [ tcga ]
S392 Y392 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S441 A441 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S472 F472 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
T477 S477 Biomuta DOID:1324 / lung cancer [ tcga ]
K526 Q526 Biomuta DOID:363 / uterine cancer [ tcga ]
K526 N526 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S554 Y554 Biomuta DOID:363 / uterine cancer [ tcga ]
S557 N557 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S565 T565 Biomuta DOID:363 / uterine cancer [ tcga ]
S569 P569 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T608 N608 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T618 M618 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S627 L627 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S640 N640 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S910 Y910 Biomuta DOID:363 / uterine cancer [ tcga ]
S1012 P1012 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1251 T1251 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1259 L1259 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S1287 F1287 Biomuta DOID:363 / uterine cancer [ tcga ]
K1316 N1316 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1331 P1331 Biomuta DOID:1319 / brain cancer [ icgc ]
K1456 N1456 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1587 R1587 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
S1674 Y1674 Biomuta DOID:363 / uterine cancer [ tcga ]
T1724 S1724 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1774 F1774 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K1776 T1776 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]