iPTMnet Report for Q02880 (TOP2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02880 / TOP2B_HUMAN
Protein Name DNA topoisomerase 2-beta
Gene Name Name: TOP2B
Organism Homo sapiens (Human)

PRO ID PR:Q02880
DAG View
PRO Name DNA topoisomerase 2-beta (human)
Definition A DNA topoisomerase 2-beta that is encoded in the genome of human.
Short Label hTOP2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02880 (TOP2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Sumoylation PRO
S4 Phosphorylation PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K228 Sumoylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K365 Acetylation PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K373 Acetylation PhosphoSitePlus
K373 Sumoylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K412 Methylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K421 Methylation PhosphoSitePlus
K439 Methylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K452 Acetylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
K461 Sumoylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
S473 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...34725712, 34019948, 32119511
T477 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...34725712, 34019948, 32119511
K487 Ubiquitination PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K510 Sumoylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K587 Methylation PhosphoSitePlus
K600 Sumoylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K621 Acetylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
T639 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S640 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K643 Sumoylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K646 Sumoylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K683 Sumoylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
R693 Methylation PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
C754 Methylation IEDB 31844290
K756 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
Y851 Phosphorylation PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
Y888 Phosphorylation PhosphoSitePlus
Y913 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
K979 Acetylation PhosphoSitePlus
K979 Ubiquitination PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
K992 Acetylation PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
K1008 Acetylation PhosphoSitePlus
K1008 Ubiquitination PhosphoSitePlus
K1032 Sumoylation PhosphoSitePlus
K1032 Ubiquitination PhosphoSitePlus
K1068 Ubiquitination PhosphoSitePlus
K1079 Ubiquitination PhosphoSitePlus
K1083 Ubiquitination PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus
S1133 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
T1137 Phosphorylation PhosphoSitePlus
S1139 Phosphorylation PhosphoSitePlus
K1164 Ubiquitination PhosphoSitePlus
S1212 Phosphorylation PhosphoSitePlus
K1214 Ubiquitination PhosphoSitePlus
K1227 Sumoylation PhosphoSitePlus
K1227 Ubiquitination PhosphoSitePlus
T1233 Phosphorylation PhosphoSitePlus
S1236 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
T1247 Phosphorylation PhosphoSitePlus
K1250 Sumoylation PhosphoSitePlus
K1250 Ubiquitination PhosphoSitePlus
K1255 Acetylation PhosphoSitePlus
K1259 Acetylation PhosphoSitePlus
K1260 Acetylation PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
T1267 Phosphorylation PhosphoSitePlus
K1271 Sumoylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
T1292 Phosphorylation PhosphoSitePlus   UniProt 19690332
K1299 Ubiquitination PhosphoSitePlus
K1302 Ubiquitination PhosphoSitePlus
K1307 Acetylation PhosphoSitePlus
T1317 Phosphorylation PhosphoSitePlus
K1323 Acetylation PhosphoSitePlus
K1323 Ubiquitination PhosphoSitePlus
K1327 Acetylation PhosphoSitePlus
K1328 Acetylation PhosphoSitePlus
S1336 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...17081983
S1340 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...20068231
S1342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S1344 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
T1349 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus   UniProt 21406692
R1362 Methylation PhosphoSitePlus
R1367 Methylation PhosphoSitePlus
Y1370 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1371 Phosphorylation PhosphoSitePlus
S1375 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S1400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 24275569, 19690332, 20068231
T1403 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1413 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 24275569, 19690332, 20068231
Y1421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1422 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1424 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18234856, 18669648, 19690332, 20068231
S1428 Phosphorylation PhosphoSitePlus
T1431 Phosphorylation PhosphoSitePlus
K1434 Acetylation PhosphoSitePlus
S1435 Phosphorylation PhosphoSitePlus
K1440 Sumoylation PhosphoSitePlus
K1440 Ubiquitination PhosphoSitePlus
S1441 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S1449 Phosphorylation PhosphoSitePlus
S1452 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
Y1453 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1454 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 21406692, ...18669648, 20068231
K1456 Sumoylation PhosphoSitePlus
K1456 Ubiquitination PhosphoSitePlus
S1457 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1461 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S1466 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S1471 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16565220
S1473 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1476 Phosphorylation PhosphoSitePlus   UniProt 19690332, 20068231
K1482 Ubiquitination PhosphoSitePlus
K1486 Acetylation PhosphoSitePlus
S1501 Phosphorylation PhosphoSitePlus
S1522 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 19690332, 20068231
S1524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...16565220, 18669648, 24275569, 19690332, 20068231
S1526 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S1550 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569
S1552 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...24275569
K1574 Ubiquitination PhosphoSitePlus
T1575 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569, ...18220336
S1576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S1581 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18220336, ...18669648, 24275569, 19690332
S1588 Phosphorylation PhosphoSitePlus
T1592 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1596 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1600 Phosphorylation PhosphoSitePlus
Y1609 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1613 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
K28 Sumoylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S32 Phosphorylation HPRD 18491316
S40 Phosphorylation HPRD 18491316
S41 Phosphorylation HPRD 18491316
Y98 Phosphorylation HPRD 20068231
Y152 Phosphorylation HPRD 18452278
T634 Phosphorylation HPRD 17081983, 20068230
S635 Phosphorylation HPRD 17081983, 20068230
S971 Phosphorylation HPRD 20068231
Y973 Phosphorylation HPRD 20068231
S1126 Phosphorylation HPRD 18452278
S1127 Phosphorylation HPRD 18452278
S1128 Phosphorylation HPRD 18452278
S1130 Phosphorylation HPRD   PhosphoSitePlus 18452278
T1132 Phosphorylation HPRD 18452278
S1134 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1207 Phosphorylation HPRD 20068231
S1231 Phosphorylation HPRD 18669648, 19691289, 20068231, ...17924679
T1287 Phosphorylation HPRD 20068231
S1331 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S1335 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1337 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S1339 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
Y1365 Phosphorylation HPRD 18669648
T1366 Phosphorylation HPRD 17081983, 18452278
S1370 Phosphorylation HPRD 18669648, 18452278
S1395 Phosphorylation HPRD   PhosphoSitePlus 17081983, 19691289, 18452278, ...19651622, 18669648, 20166139, 20068231
T1398 Phosphorylation HPRD 20068231, 18452278
S1408 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
Y1416 Phosphorylation HPRD 18669648
T1417 Phosphorylation HPRD 20068231
S1419 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231, ...18452278
T1426 Phosphorylation PhosphoSitePlus
S1436 Phosphorylation HPRD 19651622, 20068231
S1447 Phosphorylation HPRD 20068231
Y1448 Phosphorylation HPRD 18669648, 18452278
S1449 Phosphorylation HPRD 17525332, 18669648, 20068231
S1452 Phosphorylation HPRD 18669648, 18452278
S1456 Phosphorylation HPRD 18669648, 18452278
S1461 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S1466 Phosphorylation HPRD 19651622, 18669648, 16565220, ...20068231, 18452278
S1468 Phosphorylation HPRD 18452278
S1471 Phosphorylation HPRD 20068231, 18452278
S1496 Phosphorylation HPRD 19691289
S1517 Phosphorylation HPRD 19413330, 20058876, 15302935, ...19664994, 19691289, 18452278, 19651622, 18669648, 20166139, 16565220, 19415658, 20068231
S1519 Phosphorylation HPRD 19413330, 20058876, 19691289, ...18452278, 19651622, 18669648, 20166139, 16565220, 19415658, 20068231
S1521 Phosphorylation HPRD 19413330, 17322306, 18452278, ...19651622, 18669648, 20068231
S1545 Phosphorylation HPRD   PhosphoSitePlus 18212344, 18452278, 19651622, ...18669648, 20068231, 17081983
S1547 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
Y1553 Phosphorylation HPRD 17081983
T1570 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1571 Phosphorylation HPRD 18669648, 17081983, 18452278
S1576 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T1587 Phosphorylation HPRD 18669648
S1591 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
Y1604 Phosphorylation HPRD 18669648
S1608 Phosphorylation HPRD 18669648, 20058876, 17081983, ...20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049510 (hTOP2B/SumoLys+) su PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 L41 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S46 L46 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y152 S152 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y157 S157 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K189 T189 Biomuta DOID:263 / kidney cancer [ cosmic ]
K221 N221 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K308 N308 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K342 N342 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K418 N418 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K418 Q418 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T477 I477 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y539 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y539 F539 Biomuta DOID:1612 / breast cancer [ cosmic ]
K556 R556 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K600 N600 Biomuta DOID:363 / uterine cancer [ icgc ]
K605 T605 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T634 I634 Biomuta DOID:1612 / breast cancer [ cosmic ]
T639 I639 Biomuta DOID:1612 / breast cancer [ cosmic ]
K643 N643 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K646 R646 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K646 N646 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K683 R683 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R693 Q693 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S730 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S738 F738 Biomuta DOID:4159 / skin cancer [ cosmic ]
K884 Q884 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y928 C928 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1008 N1008 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1008 E1008 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1032 R1032 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1109 R1109 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1255 E1255 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K1307 N1307 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1331 P1331 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1336 P1336 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R1362 I1362 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1367 I1367 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1456 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S1461 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S1461 N1461 Biomuta DOID:363 / uterine cancer [ icgc ]
S1466 N1466 Biomuta DOID:363 / uterine cancer [ icgc ]
S1466 C1466 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1471 L1471 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1471 C1471 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1476 L1476 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1486 T1486 Biomuta DOID:363 / uterine cancer [ icgc ]
S1519 L1519 Biomuta DOID:363 / uterine cancer [ icgc ]
S1524 L1524 Biomuta DOID:363 / uterine cancer [ icgc ]
S1571 Y1571 Biomuta DOID:363 / uterine cancer [ icgc ]
S1576 L1576 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1576 Y1576 Biomuta DOID:363 / uterine cancer [ icgc ]
S1581 L1581 Biomuta DOID:4159 / skin cancer [ cosmic ]