Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02779 / M3K10_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 10
Gene Name Name: MAP3K10
Synonyms:MLK2,MST;
Organism Homo sapiens (Human)

PRO ID PR:Q02779
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 10 (human)
Definition A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human.
Short Label hMAP3K10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02779 (MAP3K10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S225 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S489 Phosphorylation HPRD   PhosphoSitePlus 18691976
S498 Phosphorylation PhosphoSitePlus   UniProt 19369195
S502 Phosphorylation PhosphoSitePlus   UniProt 19369195
S506 Phosphorylation PhosphoSitePlus   UniProt 19690332
S508 Phosphorylation PhosphoSitePlus
T558 Phosphorylation PhosphoSitePlus   UniProt 19369195
S589 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus


Q02779 (MAP3K10) as PTM Enzyme



Substrate Site Score Source PMID
P13688-1 (CEACAM1) S508 HPRD 11850617
P15923 (TCF3) S341 PhosphoSitePlus   Signor 19801649
P15923 (TCF3) S352 PhosphoSitePlus   Signor 19801649
P15923 (TCF3) T355 PhosphoSitePlus   Signor 19801649
P15923 (TCF3) S359 PhosphoSitePlus   Signor 19801649
P15923 (TCF3) S379 PhosphoSitePlus   Signor 19801649
P45985 (MAP2K4) T261 neXtProt 9182538
Q92630 (DYRK2) T381 neXtProt   PhosphoSitePlus 18455992
Q92630 (DYRK2) S449 neXtProt   PhosphoSitePlus 18455992


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S498 Y498 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S498 F498 Biomuta DOID:363 / uterine cancer [ tcga ]
S589 N589 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]