iPTMnet Report for Q02779 (MAP3K10)
Protein Information
| UniProt AC / UniProt ID | Q02779 / M3K10_HUMAN |
| Protein Name | Mitogen-activated protein kinase kinase kinase 10 |
| Gene Name | Name: MAP3K10 Synonyms:MLK2,MST; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q02779 |
| PRO Name | mitogen-activated protein kinase kinase kinase 10 (human) |
| Definition | A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human. |
| Short Label | hMAP3K10 |
| Category | organism-gene |
DAG ViewQ02779 (MAP3K10) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S225 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S446 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S489 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18691976 | ||
| S498 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S502 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S506 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
| S508 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T558 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S589 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S722 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S809 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S830 | Phosphorylation | score1 | PhosphoSitePlus |
Q02779 (MAP3K10) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P13688-1 (CEACAM1) | S508 | score1 | HPRD | 11850617 | |
| P15923 (TCF3) | S341 | score3 | PhosphoSitePlus Signor | 19801649 | |
| P15923 (TCF3) | S352 | score3 | PhosphoSitePlus Signor | 19801649 | |
| P15923 (TCF3) | T355 | score3 | PhosphoSitePlus Signor | 19801649 | |
| P15923 (TCF3) | S359 | score3 | PhosphoSitePlus Signor | 19801649 | |
| P15923 (TCF3) | S379 | score3 | PhosphoSitePlus Signor | 19801649 | |
| P45985 (MAP2K4) | T261 | score2 | neXtProt | 9182538 | |
| Q92630 (DYRK2) | T381 | score3 | neXtProt PhosphoSitePlus | 18455992 | |
| Q92630 (DYRK2) | S449 | score3 | neXtProt PhosphoSitePlus | 18455992 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S498 | F498 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S508 | R508 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T558 | M558 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S589 | R589 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S589 | N589 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |
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