iPTMnet Report for Q02641 (CACNB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02641 / CACB1_HUMAN
Protein Name Voltage-dependent L-type calcium channel subunit beta-1
Gene Name Name: CACNB1
Synonyms:CACNLB1;
Organism Homo sapiens (Human)

PRO ID PR:Q02641
DAG View
PRO Name voltage-dependent L-type calcium channel subunit beta-1 (human)
Definition A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human.
Short Label hCACNB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02641 (CACNB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y31 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
S161 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt 16406008
K175 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S348 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt 16406008
S416 Phosphorylation PhosphoSitePlus
T418 Phosphorylation phospho.ELM 17081983
Y447 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
R593 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T418 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
T205 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
T463 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
T418 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 R44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y63 C63 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T248 I248 Biomuta [ cosmic ]
T418 M418 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T463 M463 Biomuta DOID:1781 / thyroid gland cancer [ cosmic, cosmic ] DOID:1781 / thyroid cancer [ icgc, icgc ]
S495 C495 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T499 S499 Biomuta DOID:1324 / lung cancer [ cosmic ]
S547 F547 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R593 Q593 Biomuta DOID:1612 / breast cancer [ cosmic ]