Protein Information

Cytoscape View

UniProt AC / UniProt ID Q02539 / H11_HUMAN
Protein Name Histone H1.1
Gene Name Name: H1-1
Organism Homo sapiens (Human)

PRO ID PR:Q02539
DAG View
PRO Name histone H1.1 (human)
Definition A histone H1.1 that is encoded in the genome of human.
Short Label hHIST1H1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q02539 (H1-1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 7499230, 20068231, 17043054
T4 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM 7499230, 17043054
K17 Ubiquitination PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Methylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T152 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 20551309
T162 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S165 Phosphorylation HPRD   PhosphoSitePlus 20068231
S166 Phosphorylation HPRD   PhosphoSitePlus 20068231
S183 Phosphorylation Q15369 (ELOC) , P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor 20551309
T204 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 L61 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S89 G89 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T95 R95 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
T95 K95 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K109 R109 Biomuta DOID:363 / uterine cancer [ tcga ]
K125 N125 Biomuta DOID:10534 / stomach cancer [ cosmic ]