iPTMnet Report for Q02447 (SP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02447 / SP3_HUMAN
Protein Name Transcription factor Sp3
Gene Name Name: SP3
Organism Homo sapiens (Human)

PRO ID PR:Q02447
DAG View
PRO Name transcription factor Sp3 (human)
Definition A transcription factor Sp3 that is encoded in the genome of human.
Short Label hSP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02447 (SP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T65 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S73 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 18669648, 24275569, ...17685427, 19690332, 20068231
T115 Phosphorylation PhosphoSitePlus
T118 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 32938750, 29351928, 34019948, 35289036, 35254053
K120 Sumoylation PhosphoSitePlus
S131 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
T134 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
S135 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
S136 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
T231 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
S375 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
S389 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
T390 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
T407 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
S408 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
T417 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
T420 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...26431879, 29351928, 34019948, 35289036, 35254053
K551 Acetylation PhosphoSitePlus   UniProt 15554904, 11812829
K551 Sumoylation PhosphoSitePlus
S563 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S566 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K593 Acetylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
R611 Methylation PhosphoSitePlus
S646 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
C658 Methylation IEDB 31844290
S665 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
T676 Phosphorylation PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
K680 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation HPRD 18669648, 20068231
S563 Phosphorylation HPRD 18669648, 20068231, 18452278
S566 Phosphorylation HPRD 18669648, 20068231
S646 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S131 G131 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S131 R131 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C658 F658 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]