iPTMnet Report for Q02297 (NRG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02297 / NRG1_HUMAN
Protein Name Pro-neuregulin-1, membrane-bound isoform precursor
Gene Name Name: NRG1
Synonyms:GGF,HGL,HRGA,NDF,SMDF;
Organism Homo sapiens (Human)

PRO ID PR:Q02297
DAG View
PRO Name pro-neuregulin-1, membrane-bound isoform (human)
Definition A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of human.
Short Label hNRG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02297 (NRG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Acetylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K15 Acetylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
S157 O-Glycosylation GlyGen 34019948, 30620550
T169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
K551 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T528 Phosphorylation HPRD 18077418
Site PTM Type PTM Enzyme Score Source PMID
S286 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 23720309
T533 Phosphorylation HPRD 18077418
Site PTM Type PTM Enzyme Score Source PMID
T525 Phosphorylation HPRD 18077418
Site PTM Type PTM Enzyme Score Source PMID
S203 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S157 L157 Biomuta DOID:1612 / breast cancer [ icgc ]
S170 Y170 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S203 C203 Biomuta DOID:3571 / liver cancer [ cosmic ]
S414 F414 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y531 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K551 N551 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K551 T551 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]