iPTMnet Report for Q02252 (ALDH6A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02252 / MMSA_HUMAN
Protein Name Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor
Gene Name Name: ALDH6A1
Synonyms:MMSDH;
Organism Homo sapiens (Human)

PRO ID PR:Q02252
DAG View
PRO Name methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (human)
Definition A methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial that is encoded in the genome of human.
Short Label hALDH6A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02252 (ALDH6A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K47 Acetylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus   UniProt 24275569
K264 Acetylation PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus   UniProt 24275569
S487 Phosphorylation PhosphoSitePlus
R492 Methylation PhosphoSitePlus
Y498 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K104 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S262 Y262 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K264 N264 Biomuta DOID:363 / uterine cancer [ icgc ]
T360 N360 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S380 F380 Biomuta DOID:10534 / stomach cancer [ cosmic ]