iPTMnet Report for Q02248 (Ctnnb1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02248 / CTNB1_MOUSE
Protein Name Catenin beta-1
Gene Name Name: Ctnnb1
Synonyms:Catnb;
Organism Mus musculus (Mouse)

PRO ID PR:Q02248
DAG View
PRO Name catenin beta-1 (mouse)
Definition A catenin beta-1 that is encoded in the genome of mouse.
Short Label mCTNNB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02248 (Ctnnb1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation RLIMS-P 31410155
K19 Ubiquitination PhosphoSitePlus
S23 O-Glycosylation GlyGen   PhosphoSitePlus 34678516, 22645316, 32848054
S23 Phosphorylation PhosphoSitePlus
S29 Phosphorylation Q9WV60 (Gsk3b) , PR:000028438 (casein kinase II (human)) PRO   PhosphoSitePlus 9233789, 12432063
S33 Phosphorylation Q9WV60 (Gsk3b) PhosphoSitePlus   RLIMS-P   UniProt 23935526, 21858154, 28848542, ...27384483, 12417018, 30568578, 9233789, 32575075, 29422917, 31413570, 20307497, 23138569, 24911876, 27572314, 29872041, 25517963, 25443287, 23071615, 25924235, 29872733, 32764573, 28114280, 31714894, 31974426, 30413815
S37 Phosphorylation Q9WV60 (Gsk3b) PhosphoSitePlus   RLIMS-P   UniProt 21858154, 28848542, 27507058, ...12417018, 30568578, 9233789, 32575075, 29422917, 31413570, 20307497, 23138569, 24911876, 27572314, 27384483, 25443287, 23071615, 25924235, 29872733, 33443517, 32764573, 28114280, 31974426, 30413815
T41 Phosphorylation Q9WV60 (Gsk3b) PhosphoSitePlus   RLIMS-P 25924235, 27384483, 32575075, ...25443287, 30568578, 29422917, 32764573, 28114280, 21858154, 28848542, 29872733, 25517963, 9233789, 23138569, 24911876, 31413570, 27572314, 31974426, 23772418, 30413815
S45 Phosphorylation Q9WV60 (Gsk3b) , Q9JMK2 (Csnk1e) , Q02956 (Prkcz) , Q8BK63 (Csnk1a1) IntAct   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 23444350, 17208333, 30419856, ...19107203, 24278135, 23935526, 25660024, 23071615, 21858154, 21183079, 17053159, 25517963, 9233789, 31413570, 21331045, 33443517
S47 Phosphorylation PhosphoSitePlus   RLIMS-P 25517963
K49 Acetylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation P05480 (Src) PhosphoSitePlus   RLIMS-P 31330317, 27572314, 10593980
T102 Phosphorylation PR:000028438 (casein kinase II (human)) PRO 12432063
T112 O-Glycosylation GlyGen 32848054
T112 Phosphorylation PR:000028438 (casein kinase II (human)) PRO 12432063
T120 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation P70451 (Fer) , P39688 (Fyn) , PR:P06241 (hFYN) , PR:P16591 (hFER) PRO   PhosphoSitePlus   RLIMS-P   UniProt 29555825, 31330317, 33898435, ...27595133, 12640114, 27292568
K158 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17242355, 17009320, 18423204, ...21183079
C213 S-Nitrosylation dbSNO 20925432
S222 Phosphorylation PhosphoSitePlus
K233 Sumoylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S246 Phosphorylation RLIMS-P 17009320
Y333 Phosphorylation RLIMS-P 30013660, 33288902
T393 Phosphorylation PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus   RLIMS-P 31330317
T551 Phosphorylation phospho.ELM   PhosphoSitePlus 17114649, 17242355
S552 Phosphorylation P31750 (Akt1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 31864412, 29449540, 25520007, ...23935526, 20133717, 21858154, 17242355, 22981369, 23474484, 28667836, 24278135, 27550469, 24911876, 26739494, 27384483, 30613263, 23691015, 20230753, 25799508, 22992673, 30792401, 32929341, 29530069, 29872733, 23308088, 33011305, 33288902, 20361929, 19118113, 25670795, 29161772, 17237784, 29497040
T556 Phosphorylation phospho.ELM   PhosphoSitePlus 17114649, 17242355
S605 Phosphorylation PhosphoSitePlus   RLIMS-P 18423204
K625 Ubiquitination PhosphoSitePlus
Y654 Phosphorylation P05480 (Src) PhosphoSitePlus   RLIMS-P 21307168, 19404440, 32681081, ...21970630, 32231574, 31330317, 33188033, 11279024, 32308412, 19104148, 10593980, 25970250
Y670 Phosphorylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21307168, 21858154, 23474484, ...23935526, 21183079, 26884171, 23691015, 33815677, 22422579, 24122933, 22981369, 17242355, 23744610, 28254818, 29140564, 31900217, 29463067, 25560280, 28583374, 29497040
T679 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
T685 Phosphorylation PhosphoSitePlus
T693 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation PRO 20307497
S37 Phosphorylation PRO 20307497


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036860 (mCTNNB1/Phos:1) pY142 PR:P06241 (hFYN) PRO 12640114
PR:000036860 (mCTNNB1/Phos:1) pY142 PR:P16591 (hFER) PRO 12640114
PR:000037187 (mCTNNB1/Phos:2) pS29,pT102,pT112 PR:000028438 (casein kinase II (human)) PRO 12432063
PR:000037516 (mCTNNB1/iso:1/Phos:11) pS33,pS37 PRO 20307497


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P15116 (Cdh2) Y860 Q02248 (Ctnnb1) unknown eFIP 32859226
Phosphorylation Q02248 (Ctnnb1) Y142 P15116 (Cdh2) increased_association eFIP 27595133
Phosphorylation Q02248 (Ctnnb1) Y142 P55284 (Cdh5) unknown eFIP 27292568
Phosphorylation Q02248 (Ctnnb1) Y654 P09803 (Cdh1) unknown eFIP 25970250


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037187 (mCTNNB1/Phos:2) increased Interaction PR:Q9WV60 (mGSK3B) PRO 12432063