iPTMnet Report for Q02224 (CENPE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02224 / CENPE_HUMAN
Protein Name Centromere-associated protein E precursor
Gene Name Name: CENPE
Organism Homo sapiens (Human)

PRO ID PR:Q02224
DAG View
PRO Name centromere-associated protein E (human)
Definition A centromere-associated protein E that is encoded in the genome of human.
Short Label hCENPE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02224 (CENPE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
T422 Phosphorylation O14965 (AURKA) , Q96GD4 (AURKB) neXtProt   phospho.ELM   PhosphoSitePlus 20691903, 16565220
K432 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S454 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K531 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
S611 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220
S613 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
T982 Phosphorylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
K986 Ubiquitination PhosphoSitePlus
K1096 Ubiquitination PhosphoSitePlus
K1105 Ubiquitination PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
T1179 Phosphorylation PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
Y1192 Phosphorylation PhosphoSitePlus
S1211 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K1261 Ubiquitination PhosphoSitePlus
T1268 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
T1316 Phosphorylation PhosphoSitePlus
T1321 Phosphorylation PhosphoSitePlus
K1336 Ubiquitination PhosphoSitePlus
S1340 Phosphorylation PhosphoSitePlus
K1369 Ubiquitination PhosphoSitePlus
Y1628 Phosphorylation PhosphoSitePlus
K1657 Ubiquitination PhosphoSitePlus
K1706 Ubiquitination PhosphoSitePlus
K1739 Ubiquitination PhosphoSitePlus
T1801 Phosphorylation PhosphoSitePlus
S1814 Phosphorylation PhosphoSitePlus
S1886 Phosphorylation PhosphoSitePlus
K1937 Ubiquitination PhosphoSitePlus
T1951 O-Glycosylation GlyGen 30379171
T1951 Phosphorylation PhosphoSitePlus
S2083 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2126 Ubiquitination PhosphoSitePlus
S2143 Phosphorylation PhosphoSitePlus
K2230 Ubiquitination PhosphoSitePlus
K2284 Ubiquitination PhosphoSitePlus
C2297 Methylation IEDB 31844290
K2350 Ubiquitination PhosphoSitePlus
S2352 Phosphorylation PhosphoSitePlus
T2363 Phosphorylation PhosphoSitePlus
S2389 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2451 Ubiquitination PhosphoSitePlus
T2540 Phosphorylation IEDB 35494241
S2581 Phosphorylation PhosphoSitePlus
T2601 Phosphorylation PhosphoSitePlus
S2605 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 9744883
S2608 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 9744883
T2612 Phosphorylation PhosphoSitePlus
S2616 Phosphorylation phospho.ELM 16565220
T2622 Phosphorylation PhosphoSitePlus
S2639 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   UniProt 9744883, 23186163
K2641 Ubiquitination PhosphoSitePlus
S2647 Phosphorylation PhosphoSitePlus   UniProt 18669648
S2649 Phosphorylation PhosphoSitePlus
S2651 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2654 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 9744883
S2664 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 19007248
T422 Phosphorylation HPRD 16565220
S454 Phosphorylation HPRD 16565220
S611 Phosphorylation HPRD 16565220
T1026 Phosphorylation HPRD 19007248
S1211 Phosphorylation HPRD 16565220
T1268 Phosphorylation HPRD 16565220
S2352 Phosphorylation HPRD 18491316
T2363 Phosphorylation HPRD 18491316
S2389 Phosphorylation HPRD 19007248
S2513 Phosphorylation HPRD 19007248
S2608 Phosphorylation HPRD 9744883
S2639 Phosphorylation HPRD 18669648, 16565220, 19691289, ...19007248
S2647 Phosphorylation HPRD 18669648
S2651 Phosphorylation HPRD 16565220
S2654 Phosphorylation HPRD 16565220
Site PTM Type PTM Enzyme Score Source PMID
K555 Ubiquitination PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:Q02224 (hCENPE) PRO 17785528
PR:P49454 (hCENPF) Interaction PR:Q02224 (hCENPE) PRO
PR:Q02224 (hCENPE) Interaction PR:O60566 (hBUB1B) PRO 17785528
PR:Q02224 (hCENPE) Interaction PR:Q9BZD4 (hNUF2) PRO
PR:Q02224 (hCENPE) Interaction PR:P49454 (hCENPF) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K227 T227 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K227 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y283 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S312 F312 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K432 N432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K602 N602 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S611 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K638 N638 Biomuta DOID:1612 / breast cancer [ cosmic ]
S702 Y702 Biomuta DOID:363 / uterine cancer [ icgc ]
S901 A901 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S985 L985 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T1268 I1268 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y1628 H1628 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1814 L1814 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2143 L2143 Biomuta [ cosmic ]
K2284 N2284 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2389 L2389 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2513 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2605 Y2605 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2651 C2651 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S2651 Y2651 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2664 L2664 Biomuta DOID:3565 / meningioma [ cosmic ]