iPTMnet Report for Q02218 (OGDH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02218 / ODO1_HUMAN
Protein Name 2-oxoglutarate dehydrogenase complex component E1 precursor
Gene Name Name: OGDH
Organism Homo sapiens (Human)

PRO ID PR:Q02218
DAG View
PRO Name 2-oxoglutarate dehydrogenase complex component E1 (human)
Definition A 2-oxoglutarate dehydrogenase complex component E1 that is encoded in the genome of human.
Short Label hOGDH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02218 (OGDH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
S261 O-Glycosylation GlyGen 16408927, 34725712, 33465208, ...34229054
K271 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
K499 Acetylation PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus   UniProt 17370265
S546 Phosphorylation PhosphoSitePlus
Y555 Phosphorylation PhosphoSitePlus
K561 Acetylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K697 Acetylation PhosphoSitePlus
T858 Phosphorylation PhosphoSitePlus
K899 Acetylation PhosphoSitePlus
K899 Ubiquitination PhosphoSitePlus
Y909 Phosphorylation PhosphoSitePlus
T928 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
K943 Acetylation PhosphoSitePlus
K947 Ubiquitination PhosphoSitePlus
Y966 Phosphorylation PhosphoSitePlus
Y968 Phosphorylation PhosphoSitePlus
K970 Acetylation PhosphoSitePlus   UniProt 19608861
K970 Ubiquitination PhosphoSitePlus
K999 Acetylation PhosphoSitePlus
K999 Ubiquitination PhosphoSitePlus
K1000 Ubiquitination PhosphoSitePlus
T1012 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S103 C103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K276 N276 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S369 F369 Biomuta DOID:4159 / skin cancer [ cosmic ]
K389 E389 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T462 I462 Biomuta DOID:363 / uterine cancer [ cosmic ]
K564 N564 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
K564 E564 Biomuta DOID:3571 / liver cancer [ cosmic ]
K697 N697 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T858 I858 Biomuta [ cosmic ]
K899 N899 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y909 C909 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T928 A928 Biomuta DOID:9256 / colorectal cancer [ cosmic ]