Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02127 / PYRD_HUMAN
Protein Name Dihydroorotate dehydrogenase (quinone), mitochondrial precursor
Gene Name Name: DHODH
Organism Homo sapiens (Human)

PRO ID PR:Q02127
DAG View
PRO Name dihydroorotate dehydrogenase (quinone), mitochondrial (human)
Definition A dihydroorotate dehydrogenase (quinone), mitochondrial that is encoded in the genome of human.
Short Label hDHODH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02127 (DHODH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
T121 Phosphorylation HPRD   PhosphoSitePlus 20058876
Y146 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y355 Phosphorylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T62 N62 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
S214 I214 Biomuta DOID:3571 / liver cancer [ icgc ]
K344 R344 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
T356 M356 Biomuta DOID:5041 / esophageal cancer [ icgc ] DOID:3953 / adrenal gland cancer [ tcga ]
T359 S359 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T359 I359 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]