iPTMnet Report for Q02108 (GUCY1A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02108 / GCYA1_HUMAN
Protein Name Guanylate cyclase soluble subunit alpha-1
Gene Name Name: GUCY1A1
Synonyms:GUC1A3,GUCSA3,GUCY1A3;
Organism Homo sapiens (Human)

PRO ID PR:Q02108
DAG View
PRO Name guanylate cyclase soluble subunit alpha-1 (human)
Definition A guanylate cyclase soluble subunit alpha-1 that is encoded in the genome of human.
Short Label hGUCY1A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02108 (GUCY1A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T285 Phosphorylation IEDB 35494241
K447 Ubiquitination PhosphoSitePlus
Y523 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
C669 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S58 N58 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S58 C58 Biomuta DOID:1324 / lung cancer [ cosmic ]
T73 A73 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S77 N77 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S77 I77 Biomuta DOID:1324 / lung cancer [ cosmic ]
S108 Y108 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K133 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K133 E133 Biomuta DOID:1324 / lung cancer [ cosmic ]
S174 C174 Biomuta DOID:1324 / lung cancer [ cosmic ]
S267 F267 Biomuta DOID:4159 / skin cancer [ cosmic ]
T285 P285 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K447 N447 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K447 T447 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]