iPTMnet Report for Q02078 (MEF2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02078 / MEF2A_HUMAN
Protein Name Myocyte-specific enhancer factor 2A
Gene Name Name: MEF2A
Synonyms:MEF2;
Organism Homo sapiens (Human)

PRO ID PR:Q02078
DAG View
PRO Name myocyte-specific enhancer factor 2A (human)
Definition A myocyte-specific enhancer factor 2A that is encoded in the genome of human.
Short Label hMEF2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02078 (MEF2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T20 Phosphorylation RLIMS-P 15735306
K23 Ubiquitination PhosphoSitePlus
K30 Phosphorylation UniProt 18669648
S59 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S98 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12586839, 18669648, 23186163
S98 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 12586839
T103 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
T108 Phosphorylation phospho.ELM   PhosphoSitePlus 12586839, 18669648
T108 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 12586839
T111 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus 12586839
S192 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 12586839
S223 Phosphorylation PhosphoSitePlus 12586839
S223 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 12586839
S235 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S246 Phosphorylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus   UniProt 19608861
T253 Phosphorylation PhosphoSitePlus
S255 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12586839, 18669648, 23186163
S280 O-Glycosylation GlyGen 34846842, 33214551, 31492838, ...29351928, 34019948, 32870666, 35289036, 35254053, 31373491, 30059200
S281 O-Glycosylation GlyGen 33214551, 32938750, 31492838, ...29351928, 34019948, 32870666, 35289036, 35254053, 30059200
S289 Phosphorylation phospho.ELM   PhosphoSitePlus 12586839
S289 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 12586839
T312 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9858528, 10849446, 10330143, ...17785444, 12586839
T312 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10849446, 9858528
T312 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9858528
T319 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12586839, 10849446, 10330143, ...9858528
T319 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10849446, 9858528
T319 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9858528
S355 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10849446, 9858528
S355 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10849446
S355 Phosphorylation Q16539 (MAPK14) neXtProt 9858528
K403 Acetylation PhosphoSitePlus
K403 Sumoylation PhosphoSitePlus
S408 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 12586839, 12691662, 16484498, ...16371476
S408 Phosphorylation Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   Signor 12691662
S408 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   Signor 12586839
S453 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12586839, 9858528
S453 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   Signor 12586839, 9858528
S457 Phosphorylation PhosphoSitePlus
S479 Phosphorylation neXtProt   PhosphoSitePlus 12586839, 9858528
S479 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 12586839, 9858528
S494 Phosphorylation PhosphoSitePlus 12586839
S494 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 12586839
S496 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T312 Phosphorylation PRO 10849446
T312 Phosphorylation PR:Q13164 (hMAPK7) PRO 10849446
T319 Phosphorylation PRO 10849446
T319 Phosphorylation PR:Q13164 (hMAPK7) PRO 10849446
S355 Phosphorylation PRO 10849446
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S98 Phosphorylation HPRD 18669648
T108 Phosphorylation HPRD 18669648
S235 Phosphorylation HPRD 18669648, 18212344, 20068231
S255 Phosphorylation HPRD 18669648
T304 Phosphorylation HPRD 10849446, 9858528
T304 Phosphorylation Q13164 (MAPK7) HPRD 10849446, 9858528
T304 Phosphorylation Q16539 (MAPK14) HPRD 10849446, 9858528
T311 Phosphorylation HPRD 10849446, 9858528
T311 Phosphorylation Q13164 (MAPK7) HPRD 10849446, 9858528
T311 Phosphorylation Q16539 (MAPK14) HPRD 10849446, 9858528
S347 Phosphorylation HPRD 10849446
S347 Phosphorylation Q13164 (MAPK7) HPRD 10849446
S400 Phosphorylation HPRD 12691662
S400 Phosphorylation Q00535 (CDK5) HPRD 12691662
S445 Phosphorylation HPRD 9858528
S445 Phosphorylation Q16539 (MAPK14) HPRD 9858528
S488 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048365 (hMEF2A/Phos:2) pS408 PRO
PR:000048366 (hMEF2A/Phos:3) pT312,pT319 PRO
PR:000029010 (hMEF2A/iso:1/Phos:1) pS355 PRO 10849446
PR:000029010 (hMEF2A/iso:1/Phos:1) pT312,pT319 PR:Q13164 (hMAPK7) PRO 10849446


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S82 L82 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S111 L111 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S235 F235 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S255 F255 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S347 L347 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S347 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S445 Y445 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]