Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01986 / MP2K1_RAT
Protein Name Dual specificity mitogen-activated protein kinase kinase 1
Gene Name Name: Map2k1
Synonyms:Mek1,Prkmk1;
Organism Rattus norvegicus (Rat)

PRO ID PR:Q01986
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 1 (rat)
Definition A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of rat.
Short Label rMAP2K1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01986 (Map2k1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K104 Acetylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S218 Phosphorylation F1M9C3 (Braf) , Q01986 (Map2k1) PhosphoSitePlus   RLIMS-P 17314031, 16565309, 8034665
S222 Phosphorylation Q01986 (Map2k1) , F1M9C3 (Braf) PhosphoSitePlus   RLIMS-P 17314031, 16565309, 8034665
T286 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus   UniProt 14993270
S298 Phosphorylation Q64303 (Pak2) , Q62829 (Pak3) , P35465 (Pak1) PhosphoSitePlus   UniProt 12876277, 17314031, 14993270
K353 Acetylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus


Q01986 (Map2k1) as PTM Enzyme



Substrate Site Score Source PMID
P04177 (Th) S31 PhosphoSitePlus 15471880
P21708 (Mapk3) T203 PhosphoSitePlus 17314031, 15567062
P21708 (Mapk3) Y205 PhosphoSitePlus 17314031, 15567062
P49950 (Bcl2) S70 PhosphoSitePlus 15994315
P63086 (Mapk1) T183 PhosphoSitePlus 17314031
P63086 (Mapk1) Y185 PhosphoSitePlus 17314031
Q01986 (Map2k1) S218 PhosphoSitePlus 17314031
Q01986 (Map2k1) S222 PhosphoSitePlus 17314031