Protein Information

Cytoscape View

UniProt AC / UniProt ID Q01974 / ROR2_HUMAN
Protein Name Tyrosine-protein kinase transmembrane receptor ROR2 precursor
Gene Name Name: ROR2
Organism Homo sapiens (Human)

PRO ID PR:Q01974
DAG View
PRO Name tyrosine-protein kinase transmembrane receptor ROR2 (human)
Definition A tyrosine-protein kinase transmembrane receptor ROR2 that is encoded in the genome of human.
Short Label hROR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q01974 (ROR2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K97 Ubiquitination PhosphoSitePlus
T157 O-Glycosylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
S447 Phosphorylation HPRD   PhosphoSitePlus 20068231
S449 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 20068231
K466 Ubiquitination PhosphoSitePlus
S469 Phosphorylation HPRD 20068231
K489 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
Y555 Phosphorylation RLIMS-P 22992069
Y624 Phosphorylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
Y645 Phosphorylation RLIMS-P 18365018
Y646 Phosphorylation PhosphoSitePlus   RLIMS-P 18365018
K647 Ubiquitination PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
Y755 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
Y824 Phosphorylation PhosphoSitePlus
S864 Phosphorylation P49841 (GSK3B) RLIMS-P   Signor 21078818
Y873 Phosphorylation PhosphoSitePlus   RLIMS-P 18365018

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S437 Y437 Biomuta DOID:1324 / lung cancer [ cosmic ]
S449 R449 Biomuta DOID:3571 / liver cancer [ icgc ]
Y555 C555 Biomuta DOID:10534 / stomach cancer [ tcga ]
Y645 C645 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
Y666 * Biomuta DOID:1324 / lung cancer [ tcga ]
Y666 H666 Biomuta DOID:363 / uterine cancer [ tcga ]
Y755 * Biomuta DOID:3571 / liver cancer [ icgc ]
S758 L758 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S762 A762 Biomuta DOID:9256 / colorectal cancer [ tcga ]