Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01970 / PLCB3_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Gene Name Name: PLCB3
Organism Homo sapiens (Human)

PRO ID PR:Q01970
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 that is encoded in the genome of human.
Short Label hPLCB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01970 (PLCB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
S26 Phosphorylation phospho.ELM 11278298
K30 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus   UniProt 21406692
S480 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus   UniProt 24275569
S495 Phosphorylation PhosphoSitePlus   UniProt 24275569
S537 Phosphorylation Q9UQM7 (CAMK2A) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 11325525, ...15302935, 16126727, 18669648, 24275569, 20068231
Y548 Phosphorylation PhosphoSitePlus
K572 Acetylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
Y746 Phosphorylation PhosphoSitePlus
K804 Ubiquitination PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
Y847 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus
T924 Phosphorylation PhosphoSitePlus
T925 Phosphorylation phospho.ELM 18669648
S926 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S931 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S933 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S934 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1029 Ubiquitination PhosphoSitePlus
Y1031 Phosphorylation PhosphoSitePlus
K1081 Acetylation PhosphoSitePlus
S1105 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31454556, 21406692, 11278298, ...30387149, 15302935, 9660757, 18450967, 18322273, 10893237
S1107 Phosphorylation PhosphoSitePlus
T1122 Phosphorylation PhosphoSitePlus
T1130 Phosphorylation PhosphoSitePlus
K1167 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation Q13976 (PRKG1) , Q13237 (PRKG2) HPRD 11278298
S537 Phosphorylation Q13554 (CAMK2B) , Q13555 (CAMK2G) HPRD 19651622, 18669648, 15302935, ...20068231
T925 Phosphorylation HPRD 18669648
S926 Phosphorylation HPRD 18669648, 20068231
S929 Phosphorylation HPRD 20068231
S931 Phosphorylation HPRD 18669648
S933 Phosphorylation HPRD 18669648
S934 Phosphorylation HPRD 18669648, 20068231
S1105 Phosphorylation Q13976 (PRKG1) , Q13237 (PRKG2) HPRD 19651622, 11278298
T1122 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S537 C537 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y746 H746 Biomuta DOID:1319 / brain cancer [ icgc ]
S911 R911 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S916 P916 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ] DOID:1115 / sarcoma [ tcga ]
T924 P924 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T925 P925 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S926 P926 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1029 N1029 Biomuta DOID:1115 / sarcoma [ tcga ]
T1122 K1122 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T1122 R1122 Biomuta DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K1167 N1167 Biomuta DOID:3571 / liver cancer [ icgc ]