iPTMnet Report for Q01959 (SLC6A3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01959 / SC6A3_HUMAN
Protein Name Sodium-dependent dopamine transporter
Gene Name Name: SLC6A3
Synonyms:DAT1;
Organism Homo sapiens (Human)

PRO ID PR:Q01959
DAG View
PRO Name sodium-dependent dopamine transporter (human)
Definition A sodium-dependent dopamine transporter that is encoded in the genome of human.
Short Label hSLC6A3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01959 (SLC6A3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   RLIMS-P 24880859
S4 Phosphorylation PhosphoSitePlus   RLIMS-P 24880859
K5 Ubiquitination PhosphoSitePlus
S7 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 23161550, 28571709, 15024426
S12 Phosphorylation PhosphoSitePlus   RLIMS-P 28571709
S13 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
S53 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 19146407
T62 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus   RLIMS-P 22514303


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16623 (STX1A) S14 Q01959 (SLC6A3) unknown eFIP 25774383


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 I4 Biomuta DOID:363 / uterine cancer [ icgc ]
S4 R4 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S7 A7 Biomuta DOID:1319 / brain cancer [ cosmic ]
S12 F12 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S13 P13 Biomuta DOID:3571 / liver cancer [ cosmic ]
T613 K613 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T613 M613 Biomuta DOID:10534 / stomach cancer [ cosmic ]