Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01844 / EWS_HUMAN
Protein Name RNA-binding protein EWS
Gene Name Name: EWSR1
Synonyms:EWS;
Organism Homo sapiens (Human)

PRO ID PR:Q01844
DAG View
PRO Name RNA-binding protein EWS (human)
Definition An RNA-binding protein EWS that is encoded in the genome of human.
Short Label hEWSR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01844 (EWSR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T79 Phosphorylation P45983 (MAPK8) , P28482 (MAPK1) , Q13535 (ATR) , Q13315 (ATM) , Q16539 (MAPK14) , Q15759 (MAPK11) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19076070
S266 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9341188, 19076070, 934118, ...11313922
Y278 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
S286 Phosphorylation PhosphoSitePlus
R292 Methylation PhosphoSitePlus
R300 Methylation PhosphoSitePlus   UniProt 11278906
R302 Methylation PhosphoSitePlus   UniProt 11278906
R304 Methylation PhosphoSitePlus   UniProt 11278906
R309 Methylation PhosphoSitePlus   UniProt 11278906
R314 Methylation PhosphoSitePlus   UniProt 11278906
R317 Methylation PhosphoSitePlus   UniProt 11278906
R321 Methylation PhosphoSitePlus   UniProt 11278906
R330 Methylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
R455 Methylation PhosphoSitePlus   UniProt 11278906
R461 Methylation PhosphoSitePlus
R464 Methylation PhosphoSitePlus   UniProt 11278906
R471 Methylation PhosphoSitePlus   UniProt 24129315, 11278906
R486 Methylation PhosphoSitePlus   UniProt 24129315
R490 Methylation PhosphoSitePlus   UniProt 18320585, 11278906
R494 Methylation PhosphoSitePlus   UniProt 11278906
R500 Methylation PhosphoSitePlus   UniProt 11278906
R503 Methylation PhosphoSitePlus   UniProt 11278906
R506 Methylation PhosphoSitePlus   UniProt 11278906
R563 Methylation PhosphoSitePlus   UniProt 11278906
R565 Methylation PhosphoSitePlus   UniProt 11278906
R572 Methylation PhosphoSitePlus   UniProt 11278906, 18320585
R575 Methylation PhosphoSitePlus   UniProt 11278906
R581 Methylation PhosphoSitePlus   UniProt 11278906
R589 Methylation PhosphoSitePlus   UniProt 11278906
R592 Methylation PhosphoSitePlus   UniProt 11278906
R596 Methylation PhosphoSitePlus   UniProt 11278906, 18320585
R600 Methylation PhosphoSitePlus   UniProt 11278906
R603 Methylation PhosphoSitePlus   UniProt 18320585, 11278906
R607 Methylation PhosphoSitePlus   UniProt 11278906, 18320585
R614 Methylation PhosphoSitePlus
R615 Methylation PhosphoSitePlus   UniProt 24129315, 11278906
R632 Methylation PhosphoSitePlus
R633 Methylation PhosphoSitePlus   UniProt 11278906
R636 Methylation PhosphoSitePlus   UniProt 11278906
Y656 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S266 Phosphorylation P17252 (PRKCA) HPRD 9341188
S358 Phosphorylation HPRD 17081983
S371 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
R314 Methylation PhosphoSitePlus
R317 Methylation PhosphoSitePlus
R321 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S328 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S376 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S266 L266 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S286 F286 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R292 W292 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:0070003 / blastoma [ cosmic ]
R300 P300 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R304 K304 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R309 C309 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
R314 K314 Biomuta DOID:3070 / malignant glioma [ tcga ]
R321 L321 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
R330 * Biomuta DOID:363 / uterine cancer [ tcga ]
K439 I439 Biomuta DOID:1115 / sarcoma [ tcga ]
R455 W455 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R455 Q455 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R461 C461 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
R464 T464 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R464 K464 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R471 H471 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ icgc, tcga ]
R486 H486 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:2531 / hematologic cancer [ tcga ]
R486 C486 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R494 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R503 W503 Biomuta DOID:3070 / malignant glioma [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R503 P503 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R503 Q503 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R506 Q506 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R506 * Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
R563 L563 Biomuta DOID:2394 / ovarian cancer [ tcga ]
R563 H563 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
R563 C563 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R565 I565 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic ]
R565 T565 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R572 W572 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R575 I575 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R581 H581 Biomuta DOID:3571 / liver cancer [ icgc ]
R581 C581 Biomuta DOID:5041 / esophageal cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
R581 L581 Biomuta DOID:3571 / liver cancer [ icgc ]
R589 T589 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R592 C592 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R592 H592 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
R600 C600 Biomuta DOID:4362 / cervical cancer [ cosmic ]
R600 H600 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc ]
R607 Q607 Biomuta DOID:363 / uterine cancer [ tcga ]
R614 S614 Biomuta DOID:1324 / lung cancer [ cosmic ]
R615 Q615 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:3070 / malignant glioma [ cosmic ]
R632 I632 Biomuta DOID:363 / uterine cancer [ tcga ]