iPTMnet Report for Q01804 (OTUD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01804 / OTUD4_HUMAN
Protein Name OTU domain-containing protein 4
Gene Name Name: OTUD4
Synonyms:HIN-1;
Organism Homo sapiens (Human)

PRO ID PR:Q01804
DAG View
PRO Name OTU domain-containing protein 4 (human)
Definition An OTU domain-containing protein 4 that is encoded in the genome of human.
Short Label hOTUD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01804 (OTUD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
K41 Acetylation PhosphoSitePlus
Y120 Phosphorylation UniProt 29395066
S126 Phosphorylation UniProt 29395066
S128 Phosphorylation UniProt 29395066
T131 Phosphorylation UniProt 29395066
S160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   UniProt 29395066
Y169 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus   UniProt 29395066
S202 Phosphorylation PhosphoSitePlus   UniProt 29395066
S204 Phosphorylation PhosphoSitePlus   UniProt 29395066
S208 Phosphorylation PhosphoSitePlus
K266 Methylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 23186163
K343 Acetylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K344 Acetylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
R380 Methylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
Y460 Phosphorylation PhosphoSitePlus   UniProt 15144186
S495 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
Y541 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus   UniProt 23186163
S548 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
T607 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...29351928, 34019948, 31373491
S617 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...29351928, 34019948, 31373491
T619 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...29351928, 34019948, 31373491
T621 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...29351928, 34019948, 31373491
T657 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...29351928, 34019948, 31373491
K694 Ubiquitination PhosphoSitePlus
Y710 Phosphorylation PhosphoSitePlus
Y720 Phosphorylation PhosphoSitePlus
Y827 Phosphorylation PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S900 Phosphorylation PhosphoSitePlus   UniProt 20068231
S905 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
T908 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S941 Phosphorylation phospho.ELM 16964243
S987 O-Glycosylation GlyGen 31373491
T1000 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...29351928, 34019948, 31373491
S1006 O-Glycosylation GlyGen 31373491
S1006 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332, 21406692, ...16964243
S1011 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1020 Acetylation PhosphoSitePlus
S1023 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S1024 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S1031 Phosphorylation PhosphoSitePlus
K1040 Methylation PhosphoSitePlus
K1040 Ubiquitination PhosphoSitePlus
T1046 Phosphorylation PhosphoSitePlus
Y1047 Phosphorylation PhosphoSitePlus
S1049 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1050 Methylation PhosphoSitePlus
K1051 Methylation PhosphoSitePlus
K1053 Methylation PhosphoSitePlus
Y1058 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
R1061 Methylation PhosphoSitePlus
R1068 Methylation PhosphoSitePlus
Y1085 Phosphorylation PhosphoSitePlus
Y1087 Phosphorylation PhosphoSitePlus
R1089 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K167 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y120 N120 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T131 A131 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S161 F161 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K299 Q299 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K299 T299 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K347 T347 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K347 N347 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K347 I347 Biomuta DOID:363 / uterine cancer [ icgc ]
Y361 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R380 Q380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S437 F437 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y460 C460 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S495 L495 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S503 I503 Biomuta [ cosmic ]
S545 L545 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S557 F557 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S557 Y557 Biomuta DOID:3571 / liver cancer [ cosmic ]
T657 A657 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S941 F941 Biomuta [ cosmic ]
K1020 T1020 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1023 N1023 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1040 N1040 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1047 D1047 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y1058 S1058 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1068 K1068 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1085 F1085 Biomuta DOID:1612 / breast cancer [ cosmic ]
R1089 Q1089 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]