Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01780 / EXOSX_HUMAN
Protein Name Exosome component 10
Gene Name Name: EXOSC10
Synonyms:PMSCL,PMSCL2,RRP6;
Organism Homo sapiens (Human)

PRO ID PR:Q01780
DAG View
PRO Name exosome component 10 (human)
Definition An exosome component 10 that is encoded in the genome of human.
Short Label hEXOSC10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01780 (EXOSC10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
R79 Methylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K168 Sumoylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
K201 Sumoylation PhosphoSitePlus
K205 Sumoylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
K483 Sumoylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
Y491 Phosphorylation PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K642 Sumoylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
K710 Sumoylation PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
T747 Phosphorylation PhosphoSitePlus
K754 Methylation PhosphoSitePlus
T784 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
T790 Phosphorylation PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
Y818 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus   UniProt 23186163
K826 Sumoylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K835 Methylation PhosphoSitePlus
K835 Sumoylation PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
K851 Acetylation PhosphoSitePlus
K865 Acetylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
T871 Phosphorylation PhosphoSitePlus
K873 Sumoylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S490 Phosphorylation HPRD 18452278
Y491 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S490 Phosphorylation HPRD 18452278
Y491 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K136 N136 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K218 E218 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S370 P370 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y448 C448 Biomuta DOID:1324 / lung cancer [ tcga ]
K583 E583 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
K592 N592 Biomuta DOID:1612 / breast cancer [ cosmic ]
S785 I785 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T816 M816 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S821 R821 Biomuta DOID:3571 / liver cancer [ icgc ]
S866 G866 Biomuta DOID:9256 / colorectal cancer [ tcga ]