iPTMnet Report for Q01780 (EXOSC10)
Protein Information
| UniProt AC / UniProt ID | Q01780 / EXOSX_HUMAN |
| Protein Name | Exosome complex component 10 |
| Gene Name | Name: EXOSC10 Synonyms:PMSCL,PMSCL2,RRP6; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q01780 |
| PRO Name | exosome component 10 (human) |
| Definition | An exosome component 10 that is encoded in the genome of human. |
| Short Label | hEXOSC10 |
| Category | organism-gene |
Q01780 (EXOSC10) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S13 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K37 | Acetylation | score1 | PhosphoSitePlus | |||
| K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R79 | Methylation | score1 | PhosphoSitePlus | |||
| Y90 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K109 | Acetylation | score1 | PhosphoSitePlus | |||
| K136 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K150 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K168 | Sumoylation | score1 | PhosphoSitePlus | |||
| K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K186 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K201 | Sumoylation | score1 | PhosphoSitePlus | |||
| K205 | Sumoylation | score1 | PhosphoSitePlus | |||
| K210 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C288 | Methylation | score1 | IEDB | 31844290 | ||
| S370 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K417 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y419 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y446 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y448 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K483 | Sumoylation | score1 | PhosphoSitePlus | |||
| S490 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y491 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y530 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K583 | Sumoylation | score1 | PhosphoSitePlus | |||
| K583 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K591 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K592 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S593 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K633 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S636 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K642 | Sumoylation | score1 | PhosphoSitePlus | |||
| K671 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K679 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K680 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S698 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K710 | Sumoylation | score1 | PhosphoSitePlus | |||
| K710 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K716 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y718 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K725 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T747 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K754 | Methylation | score1 | PhosphoSitePlus | |||
| T784 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S785 | O-Glycosylation | score1 | GlyGen | 34725712, 33465208, 34019948, ... | ||
| S785 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T790 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K813 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T816 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y818 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S821 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K826 | Sumoylation | score1 | PhosphoSitePlus | |||
| K826 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K835 | Methylation | score1 | PhosphoSitePlus | |||
| K835 | Sumoylation | score1 | PhosphoSitePlus | |||
| T846 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S848 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K851 | Acetylation | score1 | PhosphoSitePlus | |||
| K865 | Acetylation | score1 | PhosphoSitePlus | |||
| S866 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S868 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T871 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K873 | Sumoylation | score1 | PhosphoSitePlus | |||
| S874 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K136 | N136 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| K136 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K218 | E218 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S370 | P370 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y446 | H446 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y448 | C448 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K583 | E583 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| K592 | N592 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S636 | G636 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S785 | I785 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| T790 | A790 | Biomuta | DOID:2021 / placenta cancer [ cosmic ] | |
| T816 | M816 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] |
DAG View