Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01664 / TFAP4_HUMAN
Protein Name Transcription factor AP-4
Gene Name Name: TFAP4
Synonyms:BHLHC41;
Organism Homo sapiens (Human)

PRO ID PR:Q01664
DAG View
PRO Name transcription factor AP-4 (human)
Definition A transcription factor AP-4 that is encoded in the genome of human.
Short Label hTFAP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01664 (TFAP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y3 Phosphorylation HPRD   PhosphoSitePlus 20068231
T8 Phosphorylation HPRD 20068231
K10 Ubiquitination PhosphoSitePlus
S13 Phosphorylation HPRD   PhosphoSitePlus 20068231
S30 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S123 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S124 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 17287340, ...17081983, 18220336, 19664994, 15302935, 19664995, 18452278, 19651622, 18669648, 23186163, 19415658, 20068231, 18212344
K126 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S139 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18452278, 19651622, 20068231
K147 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T8 N8 Biomuta DOID:3571 / liver cancer [ icgc ]
S30 I30 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K114 E114 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S123 L123 Biomuta DOID:4362 / cervical cancer [ tcga ]
S124 F124 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K187 * Biomuta DOID:363 / uterine cancer [ tcga ]
T282 N282 Biomuta DOID:3571 / liver cancer [ icgc ]