iPTMnet Report for Q01581 (HMGCS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01581 / HMCS1_HUMAN
Protein Name Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Gene Name Name: HMGCS1
Synonyms:HMGCS;
Organism Homo sapiens (Human)

PRO ID PR:Q01581
DAG View
PRO Name hydroxymethylglutaryl-CoA synthase, cytoplasmic (human)
Definition A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of human.
Short Label hHMGCS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01581 (HMGCS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19664995
E37 Methylation IEDB 32357974
K38 Methylation IEDB 32357974
K46 Acetylation PhosphoSitePlus   UniProt 19608861
K46 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
C69 Methylation IEDB 31844290
C86 S-Nitrosylation dbSNO 26338901
T96 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
C129 Methylation IEDB 31844290
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
C232 Methylation IEDB 31844290
K239 Acetylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
C268 Methylation IEDB 31844290
K273 Acetylation PhosphoSitePlus   UniProt 19608861
K273 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K305 Sumoylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
R313 Methylation PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
C406 Methylation IEDB 31844290
K409 Acetylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S414 Phosphorylation HPRD 20068231
K428 Ubiquitination PhosphoSitePlus
T471 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T476 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S486 Phosphorylation PhosphoSitePlus
T490 Phosphorylation HPRD 20230923
S495 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20230923, 18234856, 19664995, 19651622, 18669648, 24275569, 20166139, 19690332, 20068231
S495 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
K498 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
S516 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18491316, 23186163, 19664994, ...18452278, 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S67 T67 Biomuta DOID:1319 / brain cancer [ icgc ]
K239 N239 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C268 S268 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y310 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R313 K313 Biomuta DOID:4159 / skin cancer [ cosmic ]