iPTMnet Report for Q01484 (ANK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01484 / ANK2_HUMAN
Protein Name Ankyrin-2
Gene Name Name: ANK2
Synonyms:ANKB;
Organism Homo sapiens (Human)

PRO ID PR:Q01484
DAG View
PRO Name ankyrin-2 (human)
Definition An ankyrin-2 that is encoded in the genome of human.
Short Label hANK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01484 (ANK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S31 Phosphorylation phospho.ELM   PhosphoSitePlus 15572359
S34 Phosphorylation phospho.ELM   PhosphoSitePlus 15572359
Y50 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
R288 Methylation PhosphoSitePlus
K407 Acetylation PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
Y729 Phosphorylation PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
Y806 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
T812 Phosphorylation PhosphoSitePlus
T817 O-Glycosylation GlyGen 30379171, 28657654
T838 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus   UniProt 24275569
S890 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
R900 Methylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
S911 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S1203 Phosphorylation PhosphoSitePlus
T1221 Phosphorylation PhosphoSitePlus
S1402 Phosphorylation PhosphoSitePlus
Y1455 Phosphorylation PhosphoSitePlus
S1459 Phosphorylation PhosphoSitePlus
S1461 Phosphorylation PhosphoSitePlus
T1472 Phosphorylation PhosphoSitePlus
S1473 Phosphorylation PhosphoSitePlus
S1500 Phosphorylation PhosphoSitePlus
S1508 Phosphorylation PhosphoSitePlus
T1523 Phosphorylation PhosphoSitePlus
K1556 Acetylation PhosphoSitePlus
K1561 Acetylation PhosphoSitePlus
S1697 Phosphorylation PhosphoSitePlus
S1732 Phosphorylation PhosphoSitePlus
S1733 Phosphorylation PhosphoSitePlus
S1736 Phosphorylation PhosphoSitePlus
T1750 Phosphorylation PhosphoSitePlus
S1755 Phosphorylation PhosphoSitePlus
S1810 Phosphorylation PhosphoSitePlus
S1846 Phosphorylation PhosphoSitePlus
S1848 Phosphorylation PhosphoSitePlus
S1855 Phosphorylation PhosphoSitePlus
S1858 Phosphorylation PhosphoSitePlus
S1879 Phosphorylation PhosphoSitePlus
S1882 Phosphorylation PhosphoSitePlus
S1891 Phosphorylation PhosphoSitePlus
S1905 Phosphorylation PhosphoSitePlus
S1907 Phosphorylation PhosphoSitePlus
S1917 Phosphorylation PhosphoSitePlus
S1929 Phosphorylation PhosphoSitePlus
S1940 Phosphorylation PhosphoSitePlus
S1942 Phosphorylation PhosphoSitePlus
S1952 Phosphorylation PhosphoSitePlus
T1953 Phosphorylation PhosphoSitePlus
T1957 Phosphorylation PhosphoSitePlus
S1964 Phosphorylation PhosphoSitePlus
S1966 Phosphorylation PhosphoSitePlus
S1976 Phosphorylation PhosphoSitePlus
K1995 Acetylation PhosphoSitePlus
T2038 Phosphorylation PhosphoSitePlus
T2049 Phosphorylation PhosphoSitePlus
K2051 Acetylation PhosphoSitePlus
S2064 Phosphorylation PhosphoSitePlus
S2127 Phosphorylation PhosphoSitePlus
S2133 Phosphorylation PhosphoSitePlus
S2195 Phosphorylation PhosphoSitePlus
S2202 Phosphorylation PhosphoSitePlus
T2239 Phosphorylation PhosphoSitePlus
S2243 Phosphorylation PhosphoSitePlus
S2250 Phosphorylation PhosphoSitePlus
S2254 Phosphorylation PhosphoSitePlus
T2295 Phosphorylation PhosphoSitePlus
T2297 Phosphorylation PhosphoSitePlus
S2306 Phosphorylation PhosphoSitePlus
S2315 Phosphorylation PhosphoSitePlus
S2388 Phosphorylation PhosphoSitePlus
T2391 Phosphorylation PhosphoSitePlus
T2393 Phosphorylation PhosphoSitePlus
S2397 Phosphorylation PhosphoSitePlus
S2405 Phosphorylation PhosphoSitePlus
S2440 Phosphorylation PhosphoSitePlus
S2454 Phosphorylation PhosphoSitePlus
S2463 Phosphorylation PhosphoSitePlus
S2468 Phosphorylation PhosphoSitePlus
S2472 Phosphorylation PhosphoSitePlus
T2496 O-Glycosylation GlyGen 30379171, 28657654
S2534 Phosphorylation PhosphoSitePlus
S2537 Phosphorylation PhosphoSitePlus
T2540 Phosphorylation PhosphoSitePlus
Y2548 Phosphorylation PhosphoSitePlus
S2574 Phosphorylation PhosphoSitePlus
T2583 Phosphorylation PhosphoSitePlus
T2640 Phosphorylation PhosphoSitePlus
S2642 Phosphorylation PhosphoSitePlus
S2657 Phosphorylation PhosphoSitePlus
S2661 Phosphorylation PhosphoSitePlus
S2666 Phosphorylation PhosphoSitePlus
S2715 Phosphorylation IEDB 32357974
S2834 Phosphorylation PhosphoSitePlus
K3037 Sumoylation PhosphoSitePlus
T3079 Phosphorylation PhosphoSitePlus
T3083 Phosphorylation PhosphoSitePlus
T3087 Phosphorylation PhosphoSitePlus
T3120 O-Glycosylation GlyGen 30379171, 28657654
S3202 Phosphorylation PhosphoSitePlus
S3219 Phosphorylation PhosphoSitePlus
S3332 Phosphorylation PhosphoSitePlus
S3388 Phosphorylation PhosphoSitePlus
S3390 Phosphorylation PhosphoSitePlus
S3392 Phosphorylation PhosphoSitePlus
S3399 Phosphorylation PhosphoSitePlus
T3401 Phosphorylation PhosphoSitePlus
S3417 Phosphorylation PhosphoSitePlus
T3439 Phosphorylation PhosphoSitePlus
S3440 Phosphorylation PhosphoSitePlus
S3446 Phosphorylation PhosphoSitePlus
S3448 Phosphorylation PhosphoSitePlus
K3464 Acetylation PhosphoSitePlus
K3618 Ubiquitination PhosphoSitePlus
S3713 Phosphorylation PhosphoSitePlus
T3731 O-Glycosylation GlyGen 30379171, 28657654
S3754 Phosphorylation PhosphoSitePlus
S3792 Phosphorylation PhosphoSitePlus
S3793 Phosphorylation PhosphoSitePlus
S3795 Phosphorylation PhosphoSitePlus
T3797 Phosphorylation PhosphoSitePlus
T3803 Phosphorylation PhosphoSitePlus
Y3811 Phosphorylation PhosphoSitePlus
T3814 Phosphorylation PhosphoSitePlus
S3817 O-Glycosylation GlyGen 30379171, 28657654
S3818 Phosphorylation PhosphoSitePlus
S3823 Phosphorylation PhosphoSitePlus
S3833 Phosphorylation PhosphoSitePlus
S3839 Phosphorylation PhosphoSitePlus
S3840 Phosphorylation PhosphoSitePlus
T3844 Phosphorylation PhosphoSitePlus
S3845 Phosphorylation PhosphoSitePlus
S3851 Phosphorylation PhosphoSitePlus
Y3907 Phosphorylation PhosphoSitePlus
S3909 Phosphorylation PhosphoSitePlus
S3910 Phosphorylation PhosphoSitePlus
S3947 Phosphorylation PhosphoSitePlus
T3949 Phosphorylation PhosphoSitePlus
S3952 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 20068231
S846 Phosphorylation HPRD 18510355
S911 Phosphorylation HPRD 17287340
S1459 Phosphorylation HPRD   PhosphoSitePlus 18510355
S1461 Phosphorylation HPRD   PhosphoSitePlus 18510355
T1472 Phosphorylation PhosphoSitePlus
S1708 Phosphorylation HPRD 19413330
S1710 Phosphorylation HPRD 19413330
T1712 Phosphorylation HPRD 18510355, 19413330
S1754 Phosphorylation HPRD 18510355
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 20068231
S846 Phosphorylation HPRD 18510355
S911 Phosphorylation HPRD 17287340
S1459 Phosphorylation HPRD 18510355
S1461 Phosphorylation HPRD 18510355
S1508 Phosphorylation HPRD 17287340
T1523 Phosphorylation HPRD 17287340
S1917 Phosphorylation HPRD 20068231
S2127 Phosphorylation HPRD 18510355
S2243 Phosphorylation HPRD 18510355
S2388 Phosphorylation HPRD 20068231
S2534 Phosphorylation HPRD 18510355
S2537 Phosphorylation HPRD 18510355
T2540 Phosphorylation HPRD 18510355
T2583 Phosphorylation HPRD 17081983
S2661 Phosphorylation HPRD 20068231
S2663 Phosphorylation HPRD 20068231
S2666 Phosphorylation HPRD 20068231
S2795 Phosphorylation HPRD 20068231
S3388 Phosphorylation HPRD 18491316
S3390 Phosphorylation HPRD 18491316
S3392 Phosphorylation HPRD 18491316
T3776 Phosphorylation HPRD 15345747
S3793 Phosphorylation HPRD 19413330
S3795 Phosphorylation HPRD 19413330
T3797 Phosphorylation HPRD 18510355, 19413330
S3839 Phosphorylation HPRD 18510355
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S449 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 R12 Biomuta DOID:263 / kidney cancer [ cosmic ]
S19 R19 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T99 I99 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S105 Y105 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:1612 / breast cancer [ icgc ]
R288 Q288 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R288 * Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T532 P532 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y573 N573 Biomuta DOID:4159 / skin cancer [ cosmic ]
S670 L670 Biomuta DOID:4159 / skin cancer [ cosmic ]
T838 M838 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S898 I898 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R900 L900 Biomuta DOID:4159 / skin cancer [ cosmic ]
R900 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S901 F901 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1402 R1402 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1461 L1461 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1508 Y1508 Biomuta DOID:1319 / brain cancer [ icgc ]
T1523 I1523 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1523 K1523 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1708 F1708 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1708 Y1708 Biomuta DOID:363 / uterine cancer [ icgc ]
S1710 C1710 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1733 L1733 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1754 R1754 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1754 N1754 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1755 Y1755 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1879 L1879 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1882 L1882 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1891 P1891 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1891 F1891 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1905 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1905 L1905 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
S1907 L1907 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1917 L1917 Biomuta [ cosmic ]
S1929 L1929 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1929 W1929 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1976 Y1976 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2051 E2051 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S2243 R2243 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2250 * Biomuta [ cosmic ]
S2388 F2388 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2397 P2397 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2405 I2405 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2440 I2440 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2454 Y2454 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2463 F2463 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2534 I2534 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2657 R2657 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S2663 Y2663 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2663 F2663 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3202 A3202 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3202 F3202 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3390 F3390 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S3390 C3390 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S3392 Y3392 Biomuta DOID:363 / uterine cancer [ icgc ]
S3399 A3399 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S3399 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S3440 F3440 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3440 C3440 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S3446 R3446 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3448 G3448 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S3754 P3754 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S3793 F3793 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3793 Y3793 Biomuta DOID:363 / uterine cancer [ icgc ]
S3795 C3795 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S3839 R3839 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S3839 N3839 Biomuta DOID:3571 / liver cancer [ cosmic ]
S3840 Y3840 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T3844 I3844 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S3845 T3845 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S3851 C3851 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y3907 D3907 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S3909 F3909 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S3910 F3910 Biomuta DOID:1324 / lung cancer [ cosmic ]
T3949 I3949 Biomuta DOID:4159 / skin cancer [ cosmic ]
S3952 F3952 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3952 L3952 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]