iPTMnet Report for Q01118 (SCN7A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01118 / SCN7A_HUMAN
Protein Name Sodium channel protein type 7 subunit alpha
Gene Name Name: SCN7A
Synonyms:SCN6A;
Organism Homo sapiens (Human)

PRO ID PR:Q01118
DAG View
PRO Name sodium channel protein type 7 subunit alpha (human)
Definition A sodium channel protein type 7 subunit alpha that is encoded in the genome of human.
Short Label hSCN7A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01118 (SCN7A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y72 Phosphorylation HPRD   PhosphoSitePlus 18452278
T292 Phosphorylation PhosphoSitePlus
N309 N-Glycosylation GlyGen 29741879
S387 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
K466 Methylation PhosphoSitePlus
T636 Phosphorylation PhosphoSitePlus
K757 Acetylation PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus   UniProt 24275569
S905 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
Y990 Phosphorylation PhosphoSitePlus
S1229 O-Glycosylation GlyGen 31492838
K1505 Acetylation PhosphoSitePlus
S1511 Phosphorylation PhosphoSitePlus
T1530 Phosphorylation PhosphoSitePlus
Y1532 Phosphorylation PhosphoSitePlus
T1619 Phosphorylation PhosphoSitePlus
T1648 Phosphorylation PhosphoSitePlus
S1649 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S387 I387 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S387 G387 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y397 S397 Biomuta DOID:4159 / skin cancer [ cosmic ]
S843 T843 Biomuta DOID:3571 / liver cancer [ cosmic ]
S905 F905 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y990 C990 Biomuta DOID:4159 / skin cancer [ cosmic ]