Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01094 / E2F1_HUMAN
Protein Name Transcription factor E2F1
Gene Name Name: E2F1
Synonyms:RBBP3;
Organism Homo sapiens (Human)

PRO ID PR:Q01094
DAG View
PRO Name transcription factor E2F1 (human)
Definition A transcription factor E2F1 that is encoded in the genome of human.
Short Label hE2F1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01094 (E2F1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S31 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 23079488, 22184068, 27903963, ...25064027, 11459832
T96 Phosphorylation PhosphoSitePlus
R109 Methylation PhosphoSitePlus
R111 Methylation PhosphoSitePlus
R113 Methylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus   UniProt 10675335
K120 Acetylation PhosphoSitePlus   UniProt 10675335
S121 Phosphorylation PhosphoSitePlus
K125 Acetylation PhosphoSitePlus   UniProt 10675335
T135 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K185 Methylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S332 Phosphorylation Q9UHD2 (TBK1) , P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8087847, 27903963, 26724859
S337 Phosphorylation P06493 (CDK1) , O43318 (MAP3K7) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8087847, 27903963, 26724859
S364 Phosphorylation O96017 (CHEK2) , P49137 (MAPKAPK2) , Q683Z8 (CHK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22184068, 22558186, 22802261, ...12717439, 25064027, 23306062
S375 Phosphorylation P49336 (CDK8) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18794899, 17081983, 27903963, ...18669648, 22945643, 19690332, 7824278
S403 Phosphorylation P32780 (GTF2H1) , P49841 (GSK3B) , Q15759 (MAPK11) , O15111 (CHUK) , P50613 (CDK7) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18794805, 23796898, 27903963, ...20447425, 10428966, 17050006
T433 Phosphorylation P49841 (GSK3B) , P32780 (GTF2H1) , P50613 (CDK7) , Q15759 (MAPK11) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10428966, 18794805, 27903963, ...17050006
Site PTM Type PTM Enzyme Score Source PMID
K117 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885
K120 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885
K125 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047232 (hE2F1/PhosRes+) p PRO
PR:000028770 (hE2F1/iso:1/Ac:1) acK117,acK120,acK125 PR:000027108 (h(CBP-p300)) PRO 10753885


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06400 (RB1) S612 Q01094 (E2F1) increased_association eFIP 17380128
Phosphorylation P06400 (RB1) S612 Q01094 (E2F1) inhibited_association eFIP 17380128
Phosphorylation Q01094 (E2F1) S375 P06400 (RB1) increased_association eFIP 7824278
Phosphorylation Q01094 (E2F1) S332 P06400 (RB1) inhibited_association eFIP 25101673


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R109 Q109 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K164 N164 Biomuta DOID:9256 / colorectal cancer [ icgc ]