iPTMnet Report Q01094 E2F1

Protein Information

UniProt AC / UniProt ID	Q01094 / E2F1_HUMAN
Protein Name	Transcription factor E2F1
Gene Name	Name: E2F1 Synonyms:RBBP3;
Organism	Homo sapiens (Human)

PRO ID	PR:Q01094 DAG View
PRO Name	transcription factor E2F1 (human)
Definition	A transcription factor E2F1 that is encoded in the genome of human.
Short Label	hE2F1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q01094 (E2F1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine By position S31 T96 R109 R111 R113 K117 K120 S121 K125 T130 T135 T136 K161 K164 K185 S235 K266 S307 S332 S337 S364 S375 S403 T433	PTM Type Select all Acetylation Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 3 4	Source Select all HPRD PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
	Phosphorylation		score1	PRO
S31	Phosphorylation	Q13315 (ATM) , Q13535 (ATR)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P	23079488, 22184068, 27903963, ...25064027, 11459832
T96	Phosphorylation		score1	PhosphoSitePlus
R109	Methylation		score1	PhosphoSitePlus
R111	Methylation		score1	PhosphoSitePlus
R113	Methylation		score1	PhosphoSitePlus
K117	Acetylation		score3	PhosphoSitePlus UniProt	10675335
K120	Acetylation		score3	PhosphoSitePlus UniProt	10675335
S121	Phosphorylation		score1	PhosphoSitePlus
K125	Acetylation		score3	PhosphoSitePlus UniProt	10675335
T130	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	33110360
T135	Phosphorylation		score1	PhosphoSitePlus
T136	Phosphorylation		score1	PhosphoSitePlus
K161	Ubiquitination		score1	PhosphoSitePlus
K164	Ubiquitination		score1	PhosphoSitePlus
K185	Methylation		score3	PhosphoSitePlus UniProt	20603083
S235	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	33110360
K266	Sumoylation		score1	PhosphoSitePlus
S307	Phosphorylation		score1	PhosphoSitePlus
S332	Phosphorylation	Q9UHD2 (TBK1) , P06493 (CDK1)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	8087847, 27175585, 27903963, ...26724859
S337	Phosphorylation	P06493 (CDK1) , O43318 (MAP3K7)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	8087847, 27903963, 35678423, ...26724859
S364	Phosphorylation	O96017 (CHEK2) , P49137 (MAPKAPK2) , Q683Z8 (CHK2)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	22184068, 22558186, 22802261, ...12717439, 33174204, 25064027, 33110360, 31170959
S375	Phosphorylation	P49336 (CDK8)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18794899, 17081983, 27903963, ...18669648, 32596239, 22945643, 19690332, 7824278
S403	Phosphorylation	P32780 (GTF2H1) , P49841 (GSK3B) , Q15759 (MAPK11) , O15111 (CHUK) , P50613 (CDK7)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18794805, 23796898, 27903963, ...28992046, 20447425, 10428966, 17050006
T433	Phosphorylation	P32780 (GTF2H1) , P49841 (GSK3B) , P50613 (CDK7) , Q15759 (MAPK11)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18794805, 27903963, 33174204, ...10428966, 17050006

Search:

Site Select all By amino acid By position K117 K120 K125	PTM Type Select all Acetylation	PTM Enzyme	Score Select all 2	Source Select all PRO	PMID
K117	Acetylation	PR:000027108 (h(CBP-p300))	score2	PRO	10753885
K120	Acetylation	PR:000027108 (h(CBP-p300))	score2	PRO	10753885
K125	Acetylation	PR:000027108 (h(CBP-p300))	score2	PRO	10753885

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000028770 (hE2F1/iso:1/Ac:1) PR:000047232 (hE2F1/PhosRes+)	Sites Select all acK117,acK120,acK125 p	PTM Enzyme	Source Select all PRO	PMID
	PR:000047232 (hE2F1/PhosRes+)	p		PRO
	PR:000028770 (hE2F1/iso:1/Ac:1)	acK117,acK120,acK125	PR:000027108 (h(CBP-p300))	PRO	10753885

PTM-dependent PPI

Search:

PTM type Select all Phosphorylation	Substrate Select all P06400 (RB1) Q01094 (E2F1)	Site Select all By amino acid All Serine By position S332 S337 S375 S612	Interactant Select all P06400 (RB1) Q01094 (E2F1)	Association type Select all increased_association inhibited_association	Source Select all eFIP	PMID
Phosphorylation	P06400 (RB1)	S612	Q01094 (E2F1)	increased_association	eFIP	17380128
Phosphorylation	Q01094 (E2F1)	S337	P06400 (RB1)	increased_association	eFIP	20616879
Phosphorylation	Q01094 (E2F1)	S375	P06400 (RB1)	increased_association	eFIP	7824278
Phosphorylation	Q01094 (E2F1)	S332	P06400 (RB1)	inhibited_association	eFIP	25101673

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position R109 R113 S121 K164	Variant Select all C113 F121 N164 Q109	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ]
R109	Q109	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
R113	C113	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S121	F121	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K164	N164	Biomuta	DOID:9256 / colorectal cancer [ icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q01094 (E2F1)

Protein Information

Interactive Sequence View

Q01094 (E2F1) as Substrate

Proteoforms

PTM-dependent PPI

PTM sites affected in variants