iPTMnet Report for Q01081 (U2AF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01081 / U2AF1_HUMAN
Protein Name Splicing factor U2AF 35 kDa subunit
Gene Name Name: U2AF1
Synonyms:U2AF35,U2AFBP;ORFNames:FP793;
Organism Homo sapiens (Human)

PRO ID PR:Q01081
DAG View
PRO Name splicing factor U2AF 35 kDa subunit (human)
Definition A splicing factor U2AF 35 kDa subunit that is encoded in the genome of human.
Short Label hU2AF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01081 (U2AF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K15 Sumoylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K39 Methylation PhosphoSitePlus   UniProt 24129315
S58 Phosphorylation PhosphoSitePlus
S59 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S61 Phosphorylation PhosphoSitePlus   UniProt 21406692
C67 S-Nitrosylation dbSNO 26338901
S70 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
K92 Sumoylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
C102 S-Nitrosylation dbSNO 26338901
K116 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus   UniProt 23186163
R165 Methylation PhosphoSitePlus   UniProt 24129315
K175 Acetylation PhosphoSitePlus
K175 Methylation PhosphoSitePlus
K175 Sumoylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
R179 Methylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
R209 Methylation PhosphoSitePlus
R211 Methylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 20068231
S59 Phosphorylation HPRD 17525332, 20068231
S61 Phosphorylation HPRD 20068231
S70 Phosphorylation HPRD 20058876
T87 Phosphorylation HPRD 20058876
S195 Phosphorylation HPRD 17081983
S197 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 20068231
S195 Phosphorylation HPRD 17081983
S197 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
K39 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S122 Phosphorylation HPRD 17081983
S124 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K13 R13 Biomuta DOID:4159 / skin cancer [ cosmic ]
K15 R15 Biomuta DOID:363 / uterine cancer [ cosmic ]
S34 F34 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S34 Y34 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K39 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S58 C58 Biomuta DOID:1324 / lung cancer [ cosmic ]
S58 T58 Biomuta DOID:363 / uterine cancer [ icgc ]
R165 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R179 K179 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R209 C209 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R209 H209 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S231 L231 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]