iPTMnet Report for Q00839 (HNRNPU)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00839 / HNRPU_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein U
Gene Name Name: HNRNPU
Synonyms:C1orf199;
Organism Homo sapiens (Human)

PRO ID PR:Q00839
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein U (human)
Definition A heterogeneous nuclear ribonucleoprotein U that is encoded in the genome of human.
Short Label hHNRNPU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00839 (HNRNPU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 20068231
S2 Phosphorylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...27920218, 20068231
K9 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
K17 Sumoylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
S26 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
R50 Methylation PhosphoSitePlus
N57 N-Glycosylation GlyGen 23090970
S59 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 24275569, 23186163, ...17081983, 18220336, 27303920, 18669648, 25030905, 19351595, 25986610, 19690332, 20068231
S59 Phosphorylation P53350 (PLK1) PhosphoSitePlus 25986610
S59 Phosphorylation P78527 (PRKDC) PhosphoSitePlus   Signor 19351595
S66 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 19690332, 20068231
K181 Acetylation PhosphoSitePlus
K181 Methylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
S187 O-Glycosylation GlyGen 30444036, 31492838, 35289036, ...29237092, 34725712, 28657654, 32119511, 30397120, 35132862, 20305658, 22121020, 31373491, 35008409, 33214551, 32522876, 26853435, 30059200, 21740066, 35254053, 34019948, 35083852, 22967762, 28510447
S187 Phosphorylation PhosphoSitePlus
S188 O-Glycosylation GlyGen 30444036, 31492838, 35289036, ...29237092, 34725712, 28657654, 32119511, 30397120, 35132862, 20305658, 22121020, 31373491, 35008409, 33214551, 32522876, 26853435, 30059200, 21740066, 35254053, 34019948, 35083852, 22967762, 28510447
S188 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T191 O-Glycosylation GlyGen 31373491
T191 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S192 O-Glycosylation GlyGen 30444036, 31492838, 35289036, ...29237092, 34725712, 28657654, 32119511, 30397120, 35132862, 20305658, 22121020, 31373491, 35008409, 33214551, 32522876, 26853435, 30059200, 21740066, 35254053, 34019948, 35083852, 22967762, 28510447
S192 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T197 O-Glycosylation GlyGen 30444036, 31492838, 35289036, ...29237092, 34725712, 28657654, 32119511, 30397120, 35132862, 20305658, 22121020, 31373491, 35008409, 33214551, 32522876, 26853435, 30059200, 21740066, 35254053, 34019948, 35083852, 22967762, 28510447
K213 Acetylation PhosphoSitePlus
K215 Acetylation UniProt 19608861
K215 Methylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
R255 Methylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
K265 Acetylation PhosphoSitePlus   UniProt 19608861
K265 Sumoylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus   UniProt 23186163
S271 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 17487921, 19690332, 20068231
T286 Phosphorylation PhosphoSitePlus   UniProt 24275569
C289 Methylation IEDB 31844290
T292 Phosphorylation PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K343 Acetylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K352 Acetylation PhosphoSitePlus   UniProt 19608861
K352 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
C389 S-Nitrosylation dbSNO 26338901
C391 S-Nitrosylation dbSNO 26338901
C408 Methylation IEDB 31844290
K423 Ubiquitination PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
K489 Sumoylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
C497 S-Nitrosylation dbSNO 26338901
K510 Ubiquitination PhosphoSitePlus
K516 Acetylation PhosphoSitePlus   UniProt 19608861
K516 Methylation PhosphoSitePlus
K516 Sumoylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K524 Acetylation PhosphoSitePlus   UniProt 19608861
K524 Sumoylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus   UniProt 23186163
K536 Sumoylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K543 Acetylation PhosphoSitePlus
K543 Methylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K544 Acetylation PhosphoSitePlus
K544 Methylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
K551 Acetylation PhosphoSitePlus   UniProt 19608861
K551 Ubiquitination PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
C562 S-Nitrosylation dbSNO 19483679
K565 Acetylation PhosphoSitePlus   UniProt 19608861
K565 Ubiquitination PhosphoSitePlus
R572 Methylation PhosphoSitePlus
R575 Methylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus   UniProt 23186163
S585 Phosphorylation PhosphoSitePlus
K592 Acetylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
C594 S-Nitrosylation dbSNO 26338901
K602 Ubiquitination PhosphoSitePlus
C607 S-Nitrosylation dbSNO 26338901
K609 Acetylation PhosphoSitePlus
K609 Sumoylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
K614 Acetylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K626 Acetylation PhosphoSitePlus
K626 Sumoylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
K635 Acetylation PhosphoSitePlus   UniProt 19608861
K635 Sumoylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K637 Sumoylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
T641 O-Glycosylation GlyGen 34846842
T653 Phosphorylation PhosphoSitePlus
Y654 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
K664 Sumoylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
K670 Acetylation PhosphoSitePlus
K670 Methylation PhosphoSitePlus
K670 Sumoylation PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
K674 Acetylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
R702 Methylation PhosphoSitePlus   UniProt 24129315
R707 Methylation PhosphoSitePlus
R709 Methylation PhosphoSitePlus
R715 Methylation PhosphoSitePlus
R720 Methylation PhosphoSitePlus
R727 Methylation PhosphoSitePlus
Y730 Phosphorylation PhosphoSitePlus
R732 Methylation PhosphoSitePlus
R733 Methylation PhosphoSitePlus   UniProt 24129315
R739 Methylation PhosphoSitePlus   UniProt 24129315
Y753 Phosphorylation PhosphoSitePlus
R755 Methylation PhosphoSitePlus   UniProt 24129315
R762 Methylation PhosphoSitePlus   UniProt 24129315
R768 Methylation PhosphoSitePlus
R773 Methylation PhosphoSitePlus
R779 Methylation PhosphoSitePlus
R787 Methylation PhosphoSitePlus
R789 Methylation PhosphoSitePlus
R793 Methylation PhosphoSitePlus
S799 O-Glycosylation GlyGen 30444036, 31492838, 35289036, ...29237092, 34725712, 28657654, 32119511, 30397120, 35132862, 20305658, 22121020, 31373491, 35008409, 33214551, 32522876, 26853435, 30059200, 21740066, 35254053, 34019948, 35083852, 22967762, 28510447
S799 Phosphorylation PhosphoSitePlus
Y802 Phosphorylation PhosphoSitePlus
K814 Acetylation PhosphoSitePlus   UniProt 19608861
K814 Ubiquitination PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
Y820 Phosphorylation PhosphoSitePlus
Y824 Phosphorylation PhosphoSitePlus
Y825 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231, 20068230
S3 Phosphorylation HPRD 17081983, 20068231, 20068230
S4 Phosphorylation HPRD 19413330, 18212344, 19691289, ...19651622, 20068231, 17081983
S14 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 17287340, 20068231
S59 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 19415658, 20068231
S66 Phosphorylation HPRD 18669648, 20068231
T191 Phosphorylation HPRD 18669648, 19664995, 20068231
S192 Phosphorylation HPRD 18669648
S271 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 20058876, 19664995, 18452278, 18669648, 20187088, 20068231, 17924679
T286 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
T292 Phosphorylation HPRD 18452278
Y293 Phosphorylation HPRD 18452278
S326 Phosphorylation HPRD 20068231
Y473 Phosphorylation HPRD 15592455
Y525 Phosphorylation HPRD 20068231
Y669 Phosphorylation HPRD 20068231
S673 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231, 20068230
S3 Phosphorylation HPRD 17081983, 20068231, 20068230
S4 Phosphorylation HPRD 19413330, 18212344, 19691289, ...19651622, 20068231, 17081983
S14 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD   PhosphoSitePlus 17287340, 20068231
S59 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18220336, 19844162, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S59 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 19844162
S66 Phosphorylation HPRD   phospho.ELM 18669648, 20068231, 18220336
K181 Acetylation PhosphoSitePlus
S188 Phosphorylation phospho.ELM 18220336
T191 Phosphorylation HPRD   phospho.ELM 18669648, 19664995, 20068231, ...18220336
S192 Phosphorylation HPRD   phospho.ELM 18669648
K215 Acetylation PhosphoSitePlus
K215 Sumoylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
S252 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18491316, 17081983, ...18691976, 20058876, 19664995, 18452278, 18669648, 20187088, 20068231, 17924679
T267 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
T273 Phosphorylation HPRD 18452278
Y274 Phosphorylation HPRD 18452278
S307 Phosphorylation HPRD 20068231
K320 Acetylation PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
Y454 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y506 Phosphorylation HPRD 20068231
K524 Acetylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
Y650 Phosphorylation HPRD 20068231
S654 Phosphorylation HPRD 20068231
K795 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 F3 Biomuta DOID:4159 / skin cancer [ cosmic ]
S4 L4 Biomuta DOID:1612 / breast cancer [ cosmic ]
K28 R28 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S188 R188 Biomuta DOID:363 / uterine cancer [ cosmic ]
K213 E213 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R224 C224 Biomuta DOID:4159 / skin cancer [ cosmic ]
T267 I267 Biomuta DOID:3571 / liver cancer [ cosmic ]
S267 N267 Biomuta DOID:363 / uterine cancer [ cosmic ]
T286 I286 Biomuta DOID:3571 / liver cancer [ cosmic ]
K333 Q333 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K352 Q352 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K387 R387 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y454 C454 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K464 T464 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K464 N464 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y466 H466 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y473 C473 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T474 S474 Biomuta DOID:263 / kidney cancer [ cosmic ]
K489 E489 Biomuta DOID:1612 / breast cancer [ cosmic ]
K546 E546 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K551 N551 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K565 E565 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R572 Q572 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R575 Q575 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K619 N619 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K626 E626 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K635 T635 Biomuta DOID:363 / uterine cancer [ cosmic ]
K635 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T653 A653 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K664 N664 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K675 N675 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R707 K707 Biomuta DOID:4159 / skin cancer [ cosmic ]
R707 I707 Biomuta DOID:1324 / lung cancer [ cosmic ]
R709 C709 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
R715 C715 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R720 K720 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R727 H727 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R727 C727 Biomuta DOID:4159 / skin cancer [ cosmic ]
R732 M732 Biomuta DOID:363 / uterine cancer [ cosmic ]
R755 S755 Biomuta DOID:1324 / lung cancer [ cosmic ]
R762 H762 Biomuta DOID:363 / uterine cancer [ cosmic ]
R762 C762 Biomuta DOID:3571 / liver cancer [ cosmic ]
R779 T779 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R793 C793 Biomuta DOID:363 / uterine cancer [ cosmic ]
S799 F799 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y824 C824 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]