iPTMnet Report for Q00722 (PLCB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00722 / PLCB2_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Gene Name Name: PLCB2
Organism Homo sapiens (Human)

PRO ID PR:Q00722
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 that is encoded in the genome of human.
Short Label hPLCB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00722 (PLCB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
Y552 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
Y604 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
R874 Methylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
R893 Methylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus   UniProt 24275569
S958 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
T1035 Phosphorylation PhosphoSitePlus
S1036 Phosphorylation PhosphoSitePlus
T1040 Phosphorylation PhosphoSitePlus
K1117 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T62 Phosphorylation HPRD 18452278
S63 Phosphorylation HPRD 18452278
S728 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S63 N63 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T332 I332 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S337 T337 Biomuta DOID:1324 / lung cancer [ cosmic ]
S337 L337 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S450 I450 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S450 R450 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K761 N761 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S958 I958 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1117 N1117 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]