iPTMnet Report for Q00653 (NFKB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00653 / NFKB2_HUMAN
Protein Name Nuclear factor NF-kappa-B p100 subunit
Gene Name Name: NFKB2
Synonyms:LYT10;
Organism Homo sapiens (Human)

PRO ID PR:Q00653
DAG View
PRO Name nuclear factor NF-kappa-B p100 subunit (human)
Definition A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human.
Short Label hNFKB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00653 (NFKB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Sumoylation PhosphoSitePlus
S22 Phosphorylation phospho.ELM 18669648
S23 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K28 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K90 Sumoylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S99 Phosphorylation O15111 (CHUK) PRO   PhosphoSitePlus 15140882
S108 Phosphorylation O15111 (CHUK) PRO   PhosphoSitePlus 15140882
K112 Ubiquitination PhosphoSitePlus
S115 Phosphorylation O15111 (CHUK) PRO   PhosphoSitePlus 15140882
C120 Methylation IEDB 31844290
S123 Phosphorylation O15111 (CHUK) PRO   PhosphoSitePlus 15140882
K143 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus   UniProt 23186163
T167 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S222 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus 18669648, 20513428
K229 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
K298 Sumoylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
T429 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T651 Phosphorylation PhosphoSitePlus
T655 Phosphorylation PhosphoSitePlus
T682 Phosphorylation PhosphoSitePlus
K689 Sumoylation PhosphoSitePlus
S707 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 22388891, 22864569
S711 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 22388891, 22864569
S713 Phosphorylation PhosphoSitePlus   UniProt 8887665
S715 Phosphorylation PhosphoSitePlus   UniProt 8887665
S717 Phosphorylation PhosphoSitePlus   UniProt 8887665
S727 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus
T810 O-Glycosylation GlyGen 23301498, 35132862, 28510447, ...29351928
S812 Phosphorylation PhosphoSitePlus   UniProt 23186163
K855 Ubiquitination PhosphoSitePlus   UniProt 14676825
S858 Phosphorylation PhosphoSitePlus
T859 O-Glycosylation GlyGen 23301498, 35132862, 28510447, ...29351928
T859 Phosphorylation PhosphoSitePlus
K863 Sumoylation PhosphoSitePlus
S866 Phosphorylation Q99558 (MAP3K14) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11239468
Y868 Phosphorylation PhosphoSitePlus
S870 Phosphorylation Q99558 (MAP3K14) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11239468
S872 Phosphorylation O15111 (CHUK) phospho.ELM   PRO   PhosphoSitePlus 15310758, 15140882
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 18669648, 20068231
S23 Phosphorylation HPRD 18669648, 20068231
S220 Phosphorylation HPRD 20068231
S222 Phosphorylation HPRD 18669648
S226 Phosphorylation HPRD 20068231
S277 Phosphorylation HPRD 20068231
T429 Phosphorylation HPRD 18669648
T759 Phosphorylation HPRD 20068231
S762 Phosphorylation HPRD 20068231
T811 Phosphorylation HPRD 20068231
S816 Phosphorylation HPRD 20068231
S866 Phosphorylation HPRD 19917778
S870 Phosphorylation HPRD 19917778
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 18669648, 20068231
S23 Phosphorylation HPRD 18669648, 20068231
S220 Phosphorylation HPRD 20068231
S222 Phosphorylation HPRD 18669648
S226 Phosphorylation HPRD 20068231
S277 Phosphorylation HPRD 20068231
T429 Phosphorylation HPRD 18669648
T759 Phosphorylation HPRD 20068231
S762 Phosphorylation HPRD 20068231
T811 Phosphorylation HPRD 20068231
S816 Phosphorylation HPRD 20068231
S865 Phosphorylation Q99558 (MAP3K14) HPRD 11239468
Y867 Phosphorylation PhosphoSitePlus
S869 Phosphorylation Q99558 (MAP3K14) HPRD 11239468


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048596 (hNFKB2/Phos:2) pS99,pS108,pS115,pS123,pS866,pS870,pS872 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 Y22 Biomuta DOID:4362 / cervical cancer [ icgc ]
S23 Y23 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T97 I97 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S115 L115 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S123 F123 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K153 Q153 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S204 F204 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K235 N235 Biomuta DOID:363 / uterine cancer [ icgc ]
K252 N252 Biomuta [ cosmic ]
S277 F277 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T651 I651 Biomuta DOID:363 / uterine cancer [ icgc ]
S707 L707 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S707 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S715 L715 Biomuta DOID:4159 / skin cancer [ cosmic ]
K743 N743 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S872 T872 Biomuta DOID:1324 / lung cancer [ cosmic ]