iPTMnet Report Q00587 CDC42EP1

Protein Information

UniProt AC / UniProt ID	Q00587 / BORG5_HUMAN
Protein Name	Cdc42 effector protein 1
Gene Name	Name: CDC42EP1 Synonyms:BORG5,CEP1,MSE55;
Organism	Homo sapiens (Human)

PRO ID	PR:Q00587 DAG View
PRO Name	Cdc42 effector protein 1 (human)
Definition	A Cdc42 effector protein 1 that is encoded in the genome of human.
Short Label	hCDC42EP1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q00587 (CDC42EP1) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
R8	Methylation		score1	PhosphoSitePlus
S14	Phosphorylation		score1	PhosphoSitePlus
K17	Methylation		score1	PhosphoSitePlus
S19	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
S26	Phosphorylation		score1	PhosphoSitePlus
S27	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K30	Ubiquitination		score1	PhosphoSitePlus
T34	Phosphorylation		score1	PhosphoSitePlus
R53	Methylation		score2	PhosphoSitePlus UniProt	24129315
T61	Phosphorylation		score1	phospho.ELM	18669648
S62	Phosphorylation		score1	PhosphoSitePlus
S65	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S70	Phosphorylation		score1	PhosphoSitePlus
S71	Phosphorylation		score1	PhosphoSitePlus
S73	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T74	Phosphorylation		score1	PhosphoSitePlus
R76	Methylation		score1	PhosphoSitePlus
S77	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
R79	Methylation		score1	PhosphoSitePlus
S80	Phosphorylation		score1	PhosphoSitePlus
R98	Methylation		score1	PhosphoSitePlus
S101	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 23186163, ...20068231
S106	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S113	Phosphorylation		score2	neXtProt phospho.ELM PhosphoSitePlus UniProt	18691976, 22028470, 23186163, ...18669648, 20068231
S113	Phosphorylation	P28482 (MAPK1)	score1	neXtProt	22028470
K117	Ubiquitination		score1	PhosphoSitePlus
S121	O-Glycosylation		score1	GlyGen	31373491
S121	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 23186163, ...20068231
Y130	Phosphorylation		score1	PhosphoSitePlus
S132	O-Glycosylation		score1	GlyGen	23301498, 29485866, 31373491, ...30379171
S132	Phosphorylation		score1	PhosphoSitePlus
S142	Phosphorylation		score1	phospho.ELM	18669648
S143	Phosphorylation		score1	PhosphoSitePlus
T145	Phosphorylation		score1	PhosphoSitePlus
S146	Phosphorylation		score1	PhosphoSitePlus
S147	Phosphorylation		score1	phospho.ELM	18669648
T148	Phosphorylation		score1	PhosphoSitePlus
S152	Phosphorylation		score1	PhosphoSitePlus
Y154	Phosphorylation		score1	PhosphoSitePlus
S180	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S183	Phosphorylation		score1	PhosphoSitePlus
S190	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 18220336
S192	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 17081983, ...18220336, 18669648, 24275569, 20068231
S195	Phosphorylation		score2	neXtProt phospho.ELM PhosphoSitePlus UniProt	18669648, 22028470, 23186163, ...18220336
S195	Phosphorylation	P28482 (MAPK1)	score1	neXtProt	22028470
S302	Phosphorylation		score1	PhosphoSitePlus
S303	Phosphorylation		score1	PhosphoSitePlus
R310	Methylation		score1	PhosphoSitePlus
Y331	Phosphorylation		score1	PhosphoSitePlus
S350	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 23186163, 17081983, ...18669648, 20068231
S353	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 17081983, ...20068231
S365	Phosphorylation		score1	PhosphoSitePlus
T367	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
T12	Phosphorylation	score0	HPRD	20068231
S14	Phosphorylation	score0	HPRD	20068231
S19	Phosphorylation	score0	HPRD	19413330, 18691976
S27	Phosphorylation	score0	HPRD	19413330
T61	Phosphorylation	score0	HPRD	18669648
S65	Phosphorylation	score0	HPRD	17081983
S73	Phosphorylation	score0	HPRD	19651622, 17081983, 20068231
S101	Phosphorylation	score0	HPRD	19413330, 18691976, 18669648, ...19651622, 20068231
S106	Phosphorylation	score0	HPRD	19651622, 18669648, 20068231
S113	Phosphorylation	score0	HPRD	19413330, 18691976, 18669648, ...19651622, 20068231
S121	Phosphorylation	score0	HPRD	18691976, 19651622, 17322306, ...18669648, 20166139, 20068231
S142	Phosphorylation	score0	HPRD	18691976, 18669648
S143	Phosphorylation	score0	HPRD	19413330
T145	Phosphorylation	score0	HPRD	19413330
S147	Phosphorylation	score0	HPRD	18669648
S190	Phosphorylation	score0	HPRD	18691976, 18669648, 19664995, ...20068231
S192	Phosphorylation	score0	HPRD	19413330, 18691976, 20058876, ...19664994, 19664995, 19651622, 17322306, 18669648, 18767875, 20166139, 20068231, 17924679
S195	Phosphorylation	score0	HPRD	18669648, 19664994
S350	Phosphorylation	score0	HPRD	18691976, 18578522, 17081983, ...20058876, 19651622, 18669648, 20068231
S353	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S19	L19	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
R53	H53	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T61	M61	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S65	N65	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
R76	H76	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R79	L79	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R79	H79	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S80	C80	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
R98	K98	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S113	F113	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K117	E117	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S121	F121	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y130	H130	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S146	I146	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S147	C147	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S147	F147	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S180	F180	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S183	F183	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S192	F192	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
R310	Q310	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S365	N365	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q00587 (CDC42EP1)

Protein Information

Interactive Sequence View

Q00587 (CDC42EP1) as Substrate

PTM sites affected in variants