iPTMnet Report for Q00577 (PURA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00577 / PURA_HUMAN
Protein Name Transcriptional activator protein Pur-alpha
Gene Name Name: PURA
Synonyms:PUR1;
Organism Homo sapiens (Human)

PRO ID PR:Q00577
DAG View
PRO Name transcriptional activator protein Pur-alpha (human)
Definition A transcriptional activator protein Pur-alpha that is encoded in the genome of human.
Short Label hPURA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00577 (PURA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 21406692, 20068231
S6 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S8 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S26 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
T58 Phosphorylation HPRD 20068231
S63 Phosphorylation HPRD 20068231
K71 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
K154 Methylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
K160 Methylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
S182 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 23186163, 18220336
T183 Phosphorylation HPRD   PhosphoSitePlus 20166139
T187 Phosphorylation PhosphoSitePlus
T222 Phosphorylation HPRD 18452278
S223 Phosphorylation HPRD 18452278
K229 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 G43 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S98 N98 Biomuta DOID:363 / uterine cancer [ icgc ]
S145 R145 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y156 H156 Biomuta DOID:263 / kidney cancer [ cosmic ]
S223 A223 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y253 N253 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]