iPTMnet Report Q00537 CDK17

Protein Information

UniProt AC / UniProt ID	Q00537 / CDK17_HUMAN
Protein Name	Cyclin-dependent kinase 17
Gene Name	Name: CDK17 Synonyms:PCTAIRE2,PCTK2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q00537 DAG View
PRO Name	cyclin-dependent kinase 17 (human)
Definition	A cyclin-dependent kinase 17 that is encoded in the genome of human.
Short Label	hCDK17
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q00537 (CDK17) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S9 T11 K37 S64 S75 S80 S92 S105 S122 T124 S137 K143 S146 K160 S165 S176 S180 S182 K188 K194 K197 T202 Y203 T205 Y207 K208 K212 K221 K243 K246 K275 K315 K324 K328 K338 K423 K431 S444 K452 K459 K469 S491 K493 K499 K515 S520	PTM Type Select all Acetylation Methylation Phosphorylation Ubiquitination	Score Select all 1 2	Source Select all IEDB PhosphoSitePlus UniProt phospho.ELM	PMID
S9	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 17192257
T11	Phosphorylation	score1	PhosphoSitePlus
K37	Ubiquitination	score1	PhosphoSitePlus
S64	Phosphorylation	score1	PhosphoSitePlus
S75	Phosphorylation	score1	PhosphoSitePlus
S80	Phosphorylation	score2	PhosphoSitePlus UniProt	19369195
S92	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S105	Phosphorylation	score2	PhosphoSitePlus UniProt	19369195
S122	Phosphorylation	score1	PhosphoSitePlus
T124	Phosphorylation	score1	PhosphoSitePlus
S137	Phosphorylation	score2	IEDB phospho.ELM PhosphoSitePlus UniProt	18691976, 21406692, 23186163, ...18220336, 17192257, 19369195, 29493099
K143	Ubiquitination	score1	PhosphoSitePlus
S146	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648
K160	Ubiquitination	score1	PhosphoSitePlus
S165	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 23186163, 19369195, ...18669648, 19690332
S176	Phosphorylation	score1	PhosphoSitePlus
S180	Phosphorylation	score2	IEDB phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 17192257, ...18669648, 32387766, 19690332, 27869121
S182	Phosphorylation	score1	PhosphoSitePlus
K188	Ubiquitination	score1	PhosphoSitePlus
K194	Ubiquitination	score1	PhosphoSitePlus
K197	Ubiquitination	score1	PhosphoSitePlus
T202	Phosphorylation	score1	PhosphoSitePlus
Y203	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18083107
T205	Phosphorylation	score1	PhosphoSitePlus
Y207	Phosphorylation	score1	PhosphoSitePlus
K208	Ubiquitination	score1	PhosphoSitePlus
K212	Ubiquitination	score1	PhosphoSitePlus
K221	Ubiquitination	score1	PhosphoSitePlus
K243	Ubiquitination	score1	PhosphoSitePlus
K246	Ubiquitination	score1	PhosphoSitePlus
K275	Ubiquitination	score1	PhosphoSitePlus
K315	Ubiquitination	score1	PhosphoSitePlus
K324	Ubiquitination	score1	PhosphoSitePlus
K328	Methylation	score1	PhosphoSitePlus
K328	Ubiquitination	score1	PhosphoSitePlus
K338	Ubiquitination	score1	PhosphoSitePlus
K423	Ubiquitination	score1	PhosphoSitePlus
K431	Ubiquitination	score1	PhosphoSitePlus
S444	Phosphorylation	score1	PhosphoSitePlus
K452	Ubiquitination	score1	PhosphoSitePlus
K459	Ubiquitination	score1	PhosphoSitePlus
K469	Acetylation	score1	PhosphoSitePlus
K469	Ubiquitination	score1	PhosphoSitePlus
S491	Phosphorylation	score1	PhosphoSitePlus
K493	Ubiquitination	score1	PhosphoSitePlus
K499	Ubiquitination	score1	PhosphoSitePlus
K515	Ubiquitination	score1	PhosphoSitePlus
S520	Phosphorylation	score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S9 S105 S109 S122 T124 S137 S146 S165 S180 T202 Y203 T205 S444 S520	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0	Source Select all HPRD	PMID
S9	Phosphorylation	Q00537 (CDK17)	score0	HPRD	18691976, 18212344, 17192257
S105	Phosphorylation		score0	HPRD	18691976
S109	Phosphorylation		score0	HPRD	18691976
S122	Phosphorylation		score0	HPRD	18691976
T124	Phosphorylation		score0	HPRD	18691976
S137	Phosphorylation	Q00537 (CDK17)	score0	HPRD	18691976, 17192257
S146	Phosphorylation	Q00537 (CDK17)	score0	HPRD	18691976, 18669648, 17192257
S165	Phosphorylation		score0	HPRD	18691976, 18669648
S180	Phosphorylation	Q00537 (CDK17)	score0	HPRD	18691976, 18669648, 17192257, ...20068231
T202	Phosphorylation		score0	HPRD	18691976
Y203	Phosphorylation		score0	HPRD	18691976
T205	Phosphorylation		score0	HPRD	18691976
S444	Phosphorylation		score0	HPRD	19562805
S520	Phosphorylation		score0	HPRD	18691976

Search:

	Site Select all By amino acid All Serine By position S523	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all PhosphoSitePlus	PMID
	S523	Phosphorylation		score1	PhosphoSitePlus

Q00537 (CDK17) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all Q00537-1 (CDK17)	Site Select all By amino acid All Serine By position S9 S137 S146 S180	Score Select all 0	Source Select all HPRD	PMID
Q00537-1 (CDK17)	S9	score0	HPRD	18691976, 18212344, 17192257
Q00537-1 (CDK17)	S137	score0	HPRD	18691976, 17192257
Q00537-1 (CDK17)	S146	score0	HPRD	18691976, 18669648, 17192257
Q00537-1 (CDK17)	S180	score0	HPRD	18691976, 18669648, 17192257, ...20068231

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S9 S105 S137 S176 K194 K197 T202 K315 K459	Variant Select all * A202 E194 E315 F176 F9 N194 P105 R197 R459	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S9	F9	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S105	P105	Biomuta	DOID:363 / uterine cancer [ icgc ]
S137	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S176	F176	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K194	N194	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
K194	E194	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K197	R197	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T202	A202	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
K315	E315	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
K459	R459	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q00537 (CDK17)

Protein Information

Interactive Sequence View

Q00537 (CDK17) as Substrate

Q00537 (CDK17) as PTM Enzyme

PTM sites affected in variants