iPTMnet Report for Q00537 (CDK17)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00537 / CDK17_HUMAN
Protein Name Cyclin-dependent kinase 17
Gene Name Name: CDK17
Synonyms:PCTAIRE2,PCTK2;
Organism Homo sapiens (Human)

PRO ID PR:Q00537
DAG View
PRO Name cyclin-dependent kinase 17 (human)
Definition A cyclin-dependent kinase 17 that is encoded in the genome of human.
Short Label hCDK17
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00537 (CDK17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257
T11 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus   UniProt 19369195
S92 Phosphorylation PhosphoSitePlus   UniProt 23186163
S105 Phosphorylation PhosphoSitePlus   UniProt 19369195
S122 Phosphorylation PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
S137 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18220336, 17192257, 19369195, 29493099
K143 Ubiquitination PhosphoSitePlus
S146 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
K160 Ubiquitination PhosphoSitePlus
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...18669648, 19690332
S176 Phosphorylation PhosphoSitePlus
S180 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17192257, ...18669648, 32387766, 19690332, 27869121
S182 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T205 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K328 Methylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K469 Acetylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation Q00537 (CDK17) HPRD 18691976, 18212344, 17192257
S105 Phosphorylation HPRD 18691976
S109 Phosphorylation HPRD 18691976
S122 Phosphorylation HPRD 18691976
T124 Phosphorylation HPRD 18691976
S137 Phosphorylation Q00537 (CDK17) HPRD 18691976, 17192257
S146 Phosphorylation Q00537 (CDK17) HPRD 18691976, 18669648, 17192257
S165 Phosphorylation HPRD 18691976, 18669648
S180 Phosphorylation Q00537 (CDK17) HPRD 18691976, 18669648, 17192257, ...20068231
T202 Phosphorylation HPRD 18691976
Y203 Phosphorylation HPRD 18691976
T205 Phosphorylation HPRD 18691976
S444 Phosphorylation HPRD 19562805
S520 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S523 Phosphorylation PhosphoSitePlus


Q00537 (CDK17) as PTM Enzyme



Substrate Site Score Source PMID
Q00537-1 (CDK17) S9 HPRD 18691976, 18212344, 17192257
Q00537-1 (CDK17) S137 HPRD 18691976, 17192257
Q00537-1 (CDK17) S146 HPRD 18691976, 18669648, 17192257
Q00537-1 (CDK17) S180 HPRD 18691976, 18669648, 17192257, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 F9 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S105 P105 Biomuta DOID:363 / uterine cancer [ icgc ]
S137 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S176 F176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K194 N194 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K194 E194 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K197 R197 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T202 A202 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K315 E315 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K459 R459 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]