Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00535 / CDK5_HUMAN
Protein Name Cyclin-dependent-like kinase 5
Gene Name Name: CDK5
Synonyms:CDKN5;
Organism Homo sapiens (Human)

PRO ID PR:Q00535
DAG View
PRO Name cyclin-dependent-like kinase 5 (human)
Definition A cyclin-dependent-like kinase 5 that is encoded in the genome of human.
Short Label hCDK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00535 (CDK5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus   RLIMS-P 17713927, 23728742
Y15 Phosphorylation P54764 (EPHA4) , P06241 (FYN) , A0A173G4P4 (Abl fusion) , Q16620 (NTRK2) , P00519 (ABL1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21813649, 10896159, 17341134, ...21844361, 20673369, 14757045, 24872417, 18083107, 17143272, 14664814, 18838073, 15689152, 21209322, 23728742, 9038181, 29996940, 18948252
T17 Phosphorylation PhosphoSitePlus   UniProt 23186163
K20 Methylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K22 Methylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus   RLIMS-P 30217452
K56 Acetylation PhosphoSitePlus   UniProt 19608861
K56 Ubiquitination PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
K74 Ubiquitination PhosphoSitePlus
T77 Phosphorylation RLIMS-P 29511352
K89 Ubiquitination PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S159 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 26806339, 24498195, 29095844, ...10500146
K213 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
C290 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation HPRD 20068231
Y15 Phosphorylation P06241 (FYN) , P00519 (ABL1) HPRD 19413330, 18691976, 19901323, ...12372285, 20068231, 16497976
T17 Phosphorylation HPRD 18691976
S72 Phosphorylation HPRD 18691976
S159 Phosphorylation P48730 (CSNK1D) HPRD 10500146


Q00535 (CDK5) as PTM Enzyme



Substrate Site Score Source PMID
O00429 (DNM1L) S616 PhosphoSitePlus 25012575
O14939 (PLD2) S134 PhosphoSitePlus 18625302
O15169 (AXIN1) T481 PhosphoSitePlus 21940452
O15516 (CLOCK) T451 PhosphoSitePlus   Signor 24235147
O15516 (CLOCK) T461 PhosphoSitePlus   Signor 24235147
O43464 (HTRA2) S400 neXtProt   PhosphoSitePlus   Signor 21701498
O43602-1 (DCX) S28 HPRD 14741103
O43602-2 (DCX) S287 HPRD 14741103
O43602-1 (DCX) T289 HPRD 14741103
O43602-2 (DCX) S297 HPRD 14741103
O43602-1 (DCX) S306 HPRD 15345747, 14741103
O43602-2 (DCX) T321 HPRD 14741103
O43602-1 (DCX) T326 HPRD 14741103
O43602-2 (DCX) S327 HPRD 14741103
O43602-2 (DCX) T331 HPRD 14741103
O43602-1 (DCX) S332 HPRD 14741103
O43602-2 (DCX) S334 HPRD 14741103
O43602-1 (DCX) T336 HPRD 14741103
O43602-1 (DCX) S339 HPRD 14741103
O60260 (PRKN) S131 PhosphoSitePlus   Signor 17327227
O60331-1 (PIP5K1C) S650 HPRD   PhosphoSitePlus   Signor 17290217, 15738269
O75553-6 (DAB1) S491 HPRD 12077184
O75553-6 (DAB1) S515 HPRD 12077184
O94811 (TPPP) T14 PhosphoSitePlus 17693641
O94811 (TPPP) S18 PhosphoSitePlus 17693641
O94811 (TPPP) S160 PhosphoSitePlus 17693641
O94916 (NFAT5) T135 PhosphoSitePlus   Signor 21209322
P01106 (MYC) S62 neXtProt   PhosphoSitePlus 18408012
P04150 (NR3C1) S203 PhosphoSitePlus   Signor 17440046
P04150 (NR3C1) S211 PhosphoSitePlus   Signor 17440046
P04150 (NR3C1) S226 PhosphoSitePlus 17440046
P04156 (PRNP) S43 PhosphoSitePlus 25572400
P04626 (ERBB2) S1174 neXtProt 12824184, 17145757
P04637 (TP53) S15 PhosphoSitePlus   Signor 17591690
P04637 (TP53) S20 PhosphoSitePlus   Signor 17591690, 20673369
P04637 (TP53) S33 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 17591690, 11483158, 17117479, ...12064478
P04637 (TP53) S46 PhosphoSitePlus   RLIMS-P+   Signor 17591690, 20673369, 17117479
P04637-1 (TP53) S315 HPRD 19413330, 17287340, 19664995, ...12064478, 10884347
P05067-4 (APP) T668 neXtProt 10936190
P05067-8 (APP) T724 HPRD 8764598, 15178331, 10936190
P05067-1 (APP) T743 HPRD 8764598, 15178331, 10936190
P06400 (RB1) S795 PhosphoSitePlus 15741232
P06400 (RB1) S807 PhosphoSitePlus 15741232
P06400 (RB1) S811 PhosphoSitePlus   Signor 15741232
P07196 (NEFL) T21 PhosphoSitePlus 16452125
P07814 (EPRS) S886 PhosphoSitePlus   Signor 19647514, 21220307, 23071094
P08670 (VIM) S56 PhosphoSitePlus 21465480
P10275 (AR) S83 PhosphoSitePlus   Signor 21799006
P10275 (AR) S310 PhosphoSitePlus 25851605
P10636-6 (MAPT) S144 HPRD 19413330, 9771888, 7566346, ...12226093, 1330687, 12387894, 19415658, 9565682, 9832145, 9199504
P10636-2 (MAPT) T147 HPRD 19413330, 9546672, 11181841, ...19562805, 9199504, 12226093, 12387894, 9565682, 9832145, 9771888, 12435421
P10636-8 (MAPT) T153 PhosphoSitePlus 9614189
P10636-2 (MAPT) T154 HPRD 9546672, 11181841, 12387894, ...11311121, 9832145, 9353289
P10636-2 (MAPT) S156 HPRD 9546672, 11104762, 9614189, ...12387894, 9832145, 12435421
P10636-6 (MAPT) T159 HPRD 7566346, 9832145, 12387894, ...11181841
P10636-6 (MAPT) T173 HPRD 19651622, 17287340, 9771888, ...9199504, 12387894, 9565682, 9832145, 9353289, 9735171, 7566346, 20068231
P10636-2 (MAPT) S177 HPRD 19651622, 17287340, 9771888, ...7566346, 12387894, 9565682, 9832145, 20068231
P10636-8 (MAPT) T181 HPRD   PhosphoSitePlus 11181841, 7566346, 9771888, ...12387894, 18510355, 15994305, 9832145, 17078951, 9199504
P10636-8 (MAPT) S199 HPRD   PhosphoSitePlus 19413330, 9771888, 7566346, ...12387894, 9565682, 17078951
P10636-8 (MAPT) S202 HPRD   PhosphoSitePlus 19413330, 12226093, 19415658, ...7566346, 9771888, 9614189, 12387894, 1330687, 9565682, 15994305, 9832145, 17078951, 9199504, 26555036
P10636-8 (MAPT) T205 HPRD   PhosphoSitePlus 19413330, 12226093, 19562805, ...9199504, 11181841, 9614189, 12387894, 9565682, 9771888, 15994305, 17078951, 26555036
P10636-8 (MAPT) T212 HPRD   PhosphoSitePlus 9546672, 11181841, 9614189, ...12387894, 11311121, 17078951, 9832145, 9353289
P10636-8 (MAPT) S214 HPRD   PhosphoSitePlus 11104762, 9546672, 9614189, ...12387894, 9832145, 17078951, 12435421
P10636-8 (MAPT) T217 HPRD   PhosphoSitePlus 17078951, 7566346, 9832145, ...12387894, 11181841
P10636-8 (MAPT) T231 HPRD   PhosphoSitePlus 19651622, 17287340, 9771888, ...7566346, 12387894, 9565682, 9353289, 9832145, 17078951, 9735171, 9199504, 20068231
P10636-8 (MAPT) S235 HPRD   PhosphoSitePlus   Signor 19651622, 17287340, 9771888, ...7566346, 9614189, 12387894, 17045592, 9565682, 15994305, 9832145, 26555036, 21215781, 20068231
P10636-8 (MAPT) S262 PhosphoSitePlus 17078951
P10636-2 (MAPT) T284 HPRD 12387894
P10636-2 (MAPT) S307 HPRD 9565682, 7566346, 9832145, ...12387894, 1181841
P10636-2 (MAPT) S315 HPRD 19413330, 19651622, 9771888, ...7566346, 11181841, 12387894, 9565682, 9832145, 19415658
P10636-6 (MAPT) T315 HPRD 12387894
P10636-6 (MAPT) S338 HPRD 9565682, 7566346, 9832145, ...12387894, 1181841
P10636-6 (MAPT) S346 HPRD 19413330, 19651622, 9771888, ...7566346, 11181841, 12387894, 9565682, 9832145, 19415658
P10636-8 (MAPT) T373 HPRD 12387894
P10636-8 (MAPT) S396 HPRD   PhosphoSitePlus 7566346, 1181841, 10818091, ...12387894, 9565682, 9832145, 17078951
P10636-8 (MAPT) S404 HPRD   PhosphoSitePlus 19413330, 19651622, 9771888, ...7566346, 11181841, 10818091, 9614189, 12387894, 9565682, 15994305, 9832145, 17078951, 19415658
P10636-8 (MAPT) S409 PhosphoSitePlus 17078951
P10636-8 (MAPT) S422 HPRD   PhosphoSitePlus 17078951, 9832145, 12387894
P10636 (MAPT) T498 Signor 12387894
P10636 (MAPT) S516 Signor 12387894
P10636 (MAPT) S519 Signor 12387894, 12226093
P10636 (MAPT) T522 Signor 12387894, 12226093
P10636 (MAPT) T529 Signor 12387894
P10636 (MAPT) S531 Signor 12387894
P10636 (MAPT) T534 Signor 12387894
P10636 (MAPT) T548 Signor 21215781, 12387894
P10636 (MAPT) S552 Signor 12387894
P10636 (MAPT) S713 Signor 12387894
P10636 (MAPT) S721 Signor 12387894
P12931 (SRC) S75 HPRD   phospho.ELM   PhosphoSitePlus   Signor 10544291, 18691976, 21442427, ...19415658
P14416 (DRD2) S321 PhosphoSitePlus   Signor 24391960
P15311 (EZR) T235 HPRD   Signor 12769842
P15927 (RPA2) S23 PhosphoSitePlus 26237679
P15927 (RPA2) S29 PhosphoSitePlus 26237679
P15927 (RPA2) S33 PhosphoSitePlus 26237679
P16949 (STMN1) S38 Signor 20630875
P17600-1 (SYN1) S62 HPRD 8702879
P17600-2 (SYN1) S67 HPRD 8702879
P17600 (SYN1) S551 HPRD   Signor 8702879, 10880969
P17600-2 (SYN1) S553 HPRD   Signor 8702879, 10880969
P17706-3 (PTPN2) S304 HPRD 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
P21860-1 (ERBB3) T873 HPRD 12824184
P21860-1 (ERBB3) S1123 HPRD 12824184
P26358 (DNMT1) S154 PhosphoSitePlus   Signor 21565170
P27695 (APEX1) T233 RLIMS-P+ 21727086
P29474 (NOS3) S114 PhosphoSitePlus   Signor 20213743
P31146 (CORO1A) T424 Signor 26823173
P35222 (CTNNB1) S191 PhosphoSitePlus 17009320
P35222 (CTNNB1) S246 PhosphoSitePlus 17009320
P35612 (ADD2) S604 PhosphoSitePlus 21606488
P35612 (ADD2) S617 PhosphoSitePlus 21606488
P35612 (ADD2) S701 PhosphoSitePlus 21606488
P35968 (KDR) S229 RLIMS-P+ 27438154
P37231 (PPARG) S273 PhosphoSitePlus 21892191
P40763 (STAT3) S727 PhosphoSitePlus   RLIMS-P+   Signor 15096606, 23941877, 20516069
P41143 (OPRD1) T161 neXtProt 19295160
P41236 (PPP1R2) T73 HPRD   phospho.ELM   PhosphoSitePlus 11320080
P42858 (HTT) S432 PhosphoSitePlus 15911879
P42858 (HTT) S1179 PhosphoSitePlus   Signor 17611284
P42858 (HTT) S1199 PhosphoSitePlus   Signor 17611284
P46527 (CDKN1B) T187 RLIMS-P+ 20810788
P47989 (XDH) T222 PhosphoSitePlus 25831123
P48681 (NES) T315 HPRD 12832492, 18669648, 11278541, ...20068231
P48681 (NES) T1299 HPRD 12832492
P49023 (PXN) S85 PhosphoSitePlus 14970194
P49023-2 (PXN) S244 PhosphoSitePlus 18042622
P49418-2 (AMPH) S272 HPRD   PhosphoSitePlus 11113134
P49418-1 (AMPH) S276 HPRD   PhosphoSitePlus 11113134, 17419807
P49418-1 (AMPH) S285 HPRD   PhosphoSitePlus 11113134, 17419807
P49757 (NUMB) S288 RLIMS-P+ 25403733
P49768 (PSEN1) T354 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12056836
P53779-3 (MAPK10) T93 HPRD 11823425
P53779-1 (MAPK10) T131 HPRD   neXtProt   Signor 11823425
P56817 (BACE1) T252 PhosphoSitePlus 26317805
P62136 (PPP1CA) T320 neXtProt   PhosphoSitePlus   Signor 12202491, 17202132
Q00536-1 (CDK16) S95 HPRD 18691976, 12084709
Q00536-3 (CDK16) S101 HPRD 18691976, 12084709
Q02078-5 (MEF2A) S400 HPRD 12691662
Q02078 (MEF2A) S408 phospho.ELM   PhosphoSitePlus   Signor 12691662
Q02750-1 (MAP2K1) T286 HPRD   neXtProt 11684694, 18691976
Q02750 (MAP2K1) T292 PhosphoSitePlus 25971971
Q05193-3 (DNM1) S774 HPRD 19651622, 18088087, 12855954
Q05193-1 (DNM1) S778 HPRD 19651622, 18088087, 12855954
Q05193 (DNM1) T780 PhosphoSitePlus 17376771
Q05397 (PTK2) S732 Signor 12941275
Q05397 (PTK2) S910 PhosphoSitePlus 17692050
Q12778 (FOXO1) S249 PhosphoSitePlus 25673854
Q12879-1 (GRIN2A) S1232 HPRD 11675505
Q13153-1 (PAK1) T212 HPRD 11604394, 19413330, 19664994, ...19664995, 20058876
Q13315 (ATM) S794 PhosphoSitePlus   Signor 19151707
Q13522 (PPP1R1A) S67 neXtProt 11278334
Q13794 (PMAIP1) S13 PhosphoSitePlus   Signor 21145489
Q14194 (CRMP1) T509 PhosphoSitePlus   Signor 18003833, 16611631
Q14194 (CRMP1) S522 PhosphoSitePlus   Signor 18003833, 16611631
Q14195 (DPYSL3) T509 Signor 16611631
Q14195 (DPYSL3) T514 Signor 16611631
Q14195 (DPYSL3) S518 Signor 16611631
Q14195 (DPYSL3) S522 neXtProt   PhosphoSitePlus 26555036, 16611631
Q14814 (MEF2D) S444 neXtProt   PhosphoSitePlus 16356933, 19812325
Q15078 (CDK5R1) S8 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18326489, 17121855
Q15078 (CDK5R1) T138 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18326489, 17121855
Q15717 (ELAVL1) S202 PhosphoSitePlus 22829587
Q15833 (STXBP2) T572 phospho.ELM   Signor 17716669
Q16236 (NFE2L2) T395 PhosphoSitePlus 25909891
Q16236 (NFE2L2) S433 PhosphoSitePlus 25909891
Q16236 (NFE2L2) T439 PhosphoSitePlus 25909891
Q16555 (DPYSL2) S522 PhosphoSitePlus   RLIMS-P+ 15483118, 17902168, 26555036, ...16611631
Q16643 (DBN1) S142 PhosphoSitePlus 23979715
Q3V6T2 (CCDC88A) S1675 PhosphoSitePlus 26286990
Q5S007 (LRRK2) S1627 RLIMS-P+ 26930193
Q8IWU2 (LMTK2) S1450 PhosphoSitePlus   Signor 22220831
Q8NEB9 (PIK3C3) T159 PhosphoSitePlus   Signor 20513426
Q8NEB9 (PIK3C3) T668 PhosphoSitePlus   Signor 20513426
Q92558 (WASF1) S310 HPRD 16862120
Q92558 (WASF1) S397 HPRD 16862120
Q92558 (WASF1) S441 HPRD 16862120
Q96KR7 (PHACTR3) S318 PhosphoSitePlus 21487013
Q96RR4 (CAMKK2) S129 Signor 22778263
Q96RR4 (CAMKK2) S133 Signor 22778263
Q96RR4 (CAMKK2) S137 neXtProt   Signor 21669867, 22778263
Q99490-2 (AGAP2) S249 PhosphoSitePlus 18487454
Q99490-2 (AGAP2) S279 PhosphoSitePlus   Signor 18487454
Q99719-2 (SEPTIN5) S17 PhosphoSitePlus 17224448
Q9GZM8-1 (NDEL1) S198 HPRD 19413330, 12796778
Q9GZM8-1 (NDEL1) T219 HPRD 12796778, 18669648, 20068231
Q9GZM8-1 (NDEL1) S231 HPRD 12796778
Q9GZM8-1 (NDEL1) S242 HPRD 12796778, 20068231
Q9GZM8-1 (NDEL1) T245 HPRD 12796778, 18669648, 20068231
Q9NQT8 (KIF13B) T506 RLIMS-P+ 23077056
Q9NQX3 (GPHN) S270 RLIMS-P+ 25093719, 22778260
Q9NXR1 (NDE1) T191 PhosphoSitePlus 26206584
Q9NZ72 (STMN3) S68 PhosphoSitePlus 22577147
Q9NZ72 (STMN3) S73 PhosphoSitePlus 22577147
Q9UD71-2 (PPP1R1B) T39 HPRD 10604473
Q9UD71-1 (PPP1R1B) T75 HPRD   RLIMS-P+ 10604473, 11013232, 22820052
Q9UM11 (FZR1) S40 PhosphoSitePlus 18818692
Q9UM11 (FZR1) T121 PhosphoSitePlus 18818692
Q9UM11 (FZR1) S163 PhosphoSitePlus 18818692
Q9UQL6 (HDAC5) S279 PhosphoSitePlus 22243750
Q9Y490 (TLN1) S425 PhosphoSitePlus   Signor 19363486, 24793790


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046676 (hCDK5/Phos:1) pY15 PRO
PR:000046677 (hCDK5/Phos:2) pY15,pS159 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K237 N237 Biomuta DOID:363 / uterine cancer [ tcga ]
K268 R268 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]