iPTMnet Report for Q00403 (GTF2B)
Protein Information
UniProt AC / UniProt ID | Q00403 / TF2B_HUMAN |
Protein Name | Transcription initiation factor IIB |
Gene Name | Name: GTF2B Synonyms:TF2B,TFIIB; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q00403 |
PRO Name | transcription initiation factor IIB (human) |
Definition | A transcription initiation factor IIB that is encoded in the genome of human. |
Short Label | hGTF2B |
Category | organism-gene |
Q00403 (GTF2B) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
S5 | Phosphorylation | score0 | RLIMS-P | 20226668 | ||
Y27 | Phosphorylation | score1 | PhosphoSitePlus | |||
K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
S65 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 20226668, 23115335 | ||
S70 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S76 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 19690332 | ||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
S92 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
T123 | Phosphorylation | score1 | PhosphoSitePlus | |||
R127 | Methylation | score1 | PhosphoSitePlus | |||
K143 | Ubiquitination | score1 | PhosphoSitePlus | |||
K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
C181 | Methylation | score1 | IEDB | 31844290 | ||
C194 | Methylation | score1 | IEDB | 31844290 | ||
K238 | Acetylation | Q00403 (GTF2B) | score3 | PhosphoSitePlus UniProt | 12931194 | |
K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
T270 | Phosphorylation | score1 | PhosphoSitePlus | |||
K272 | Ubiquitination | score1 | PhosphoSitePlus | |||
T284 | Phosphorylation | score1 | PhosphoSitePlus | |||
K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
K312 | Ubiquitination | score1 | PhosphoSitePlus |
Q00403 (GTF2B) as PTM Enzyme
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q00403 (GTF2B) | S65 | Q12996 (CSTF3) | unknown | eFIP | 20226668 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K178 | R178 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
K312 | N312 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |