iPTMnet Report for Q00403 (GTF2B)
Protein Information
| UniProt AC / UniProt ID | Q00403 / TF2B_HUMAN |
| Protein Name | Transcription initiation factor IIB |
| Gene Name | Name: GTF2B Synonyms:TF2B,TFIIB; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q00403 |
| PRO Name | transcription initiation factor IIB (human) |
| Definition | A transcription initiation factor IIB that is encoded in the genome of human. |
| Short Label | hGTF2B |
| Category | organism-gene |
DAG ViewQ00403 (GTF2B) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S5 | Phosphorylation | score0 | RLIMS-P | 20226668 | ||
| Y27 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S65 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 20226668, 23115335 | ||
| S70 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S76 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 19690332 | ||
| K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S92 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T123 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R127 | Methylation | score1 | PhosphoSitePlus | |||
| K143 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C181 | Methylation | score1 | IEDB | 31844290 | ||
| C194 | Methylation | score1 | IEDB | 31844290 | ||
| K238 | Acetylation | Q00403 (GTF2B) | score3 | PhosphoSitePlus UniProt | 12931194 | |
| K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T270 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K272 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T284 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K312 | Ubiquitination | score1 | PhosphoSitePlus |
Q00403 (GTF2B) as PTM Enzyme
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q00403 (GTF2B) | S65 | Q12996 (CSTF3) | unknown | eFIP | 20226668 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K178 | R178 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| K312 | N312 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
 |