Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00341 / VIGLN_HUMAN
Protein Name Vigilin
Gene Name Name: HDLBP
Synonyms:HBP,VGL;
Organism Homo sapiens (Human)

PRO ID PR:Q00341
DAG View
PRO Name vigilin (human)
Definition A vigilin that is encoded in the genome of human.
Short Label hHDLBP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00341 (HDLBP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
T8 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 21851590, 23186163
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
K25 Ubiquitination PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
S31 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19369195, 20058876, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 19690332, 24275569, 18767875, 20166139, 19415658, 20068231
S35 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
S126 Phosphorylation HPRD 20068231
K138 Ubiquitination PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S216 Phosphorylation HPRD   PhosphoSitePlus 20068231
K221 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus   UniProt 23186163
K349 Ubiquitination PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
Y437 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
K453 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K536 Acetylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
K632 Methylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
T671 Phosphorylation HPRD   PhosphoSitePlus 20068230
K672 Ubiquitination PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
S756 Phosphorylation HPRD   PhosphoSitePlus 20068231
K769 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
K846 Ubiquitination PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K892 Methylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus
C940 S-Nitrosylation dbSNO 26338901
S944 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 15302935, 17081983, ...20068231
K991 Ubiquitination PhosphoSitePlus
S993 Phosphorylation PhosphoSitePlus
K1031 Ubiquitination PhosphoSitePlus
K1039 Ubiquitination PhosphoSitePlus
R1048 Methylation PhosphoSitePlus
K1054 Ubiquitination PhosphoSitePlus
S1056 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1058 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1062 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
T1076 Phosphorylation PhosphoSitePlus
K1108 Ubiquitination PhosphoSitePlus
Y1210 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
R1224 Methylation PhosphoSitePlus
S1236 Phosphorylation HPRD   phospho.ELM 18669648
S1237 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
K1240 Ubiquitination PhosphoSitePlus
S1247 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1252 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
T1261 Phosphorylation HPRD   PhosphoSitePlus 18212344


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 R2 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T8 S8 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K90 E90 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K197 E197 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T271 P271 Biomuta DOID:1324 / lung cancer [ tcga ]
K308 N308 Biomuta DOID:363 / uterine cancer [ tcga ]
S317 * Biomuta DOID:8618 / oral cavity cancer [ icgc ]
K453 N453 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K466 R466 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K466 N466 Biomuta DOID:1612 / breast cancer [ cosmic ]
S468 Y468 Biomuta DOID:3571 / liver cancer [ icgc ]
S468 F468 Biomuta DOID:363 / uterine cancer [ tcga ]
S468 A468 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K494 R494 Biomuta DOID:263 / kidney cancer [ cosmic ]
K526 * Biomuta DOID:1909 / melanoma [ cosmic ]
S583 L583 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K594 N594 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K605 T605 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S645 F645 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S659 F659 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
T671 A671 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K810 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S993 N993 Biomuta DOID:363 / uterine cancer [ tcga ]
R1048 W1048 Biomuta DOID:10534 / stomach cancer [ cosmic ]