iPTMnet Report for Q00266 (MAT1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00266 / METK1_HUMAN
Protein Name S-adenosylmethionine synthase isoform type-1
Gene Name Name: MAT1A
Synonyms:AMS1,MATA1;
Organism Homo sapiens (Human)

PRO ID PR:Q00266
DAG View
PRO Name S-adenosylmethionine synthase isoform type-1 (human)
Definition An S-adenosylmethionine synthetase isoform type-1 that is encoded in the genome of human.
Short Label hMAT1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00266 (MAT1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   RLIMS-P 35091576
S180 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
R264 Methylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S114 F114 Biomuta DOID:4159 / skin cancer [ cosmic ]
R264 H264 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
R264 C264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K289 N289 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T341 K341 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]