iPTMnet Report for Q00059 (TFAM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00059 / TFAM_HUMAN
Protein Name Transcription factor A, mitochondrial precursor
Gene Name Name: TFAM
Synonyms:TCF6,TCF6L2;
Organism Homo sapiens (Human)

PRO ID PR:Q00059
DAG View
PRO Name transcription factor A, mitochondrial (human)
Definition A transcription factor A, mitochondrial that is encoded in the genome of human.
Short Label hTFAM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00059 (TFAM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S48 O-Glycosylation GlyGen 23301498, 28510447, 33465208
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 23201127, 32371956
S55 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 23201127
S56 Phosphorylation PhosphoSitePlus   UniProt 23201127
S56 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 23201127
S61 Phosphorylation PhosphoSitePlus   UniProt 23201127
S61 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 23201127
K62 Ubiquitination PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Methylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
R82 Methylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
T122 Phosphorylation IEDB   PhosphoSitePlus   UniProt 35494241, 23186163, 18847512
T122 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S124 Phosphorylation PhosphoSitePlus 18847512
S124 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S128 Phosphorylation PhosphoSitePlus
K146 Methylation PhosphoSitePlus
K147 Methylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23201127, 32371956
S160 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 23201127
Y165 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S193 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S195 Phosphorylation PhosphoSitePlus   UniProt 23186163
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
T234 Phosphorylation IEDB 35494241
C246 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation HPRD 20068231
S56 Phosphorylation HPRD 20068231
S193 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K62 I62 Biomuta DOID:1324 / lung cancer [ cosmic ]
S128 F128 Biomuta DOID:4362 / cervical cancer [ icgc ]
K147 N147 Biomuta DOID:1324 / lung cancer [ cosmic ]
K190 N190 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
C246 S246 Biomuta DOID:10534 / stomach cancer [ cosmic ]