iPTMnet Report for Q00005 (PPP2R2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00005 / 2ABB_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Gene Name Name: PPP2R2B
Organism Homo sapiens (Human)

PRO ID PR:Q00005
DAG View
PRO Name serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (human)
Definition A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform that is encoded in the genome of human.
Short Label hPPP2R2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00005 (PPP2R2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 Y20 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S21 F21 Biomuta DOID:4159 / skin cancer [ cosmic ]
K125 N125 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K125 M125 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K125 R125 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K288 R288 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K288 T288 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y295 C295 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y301 H301 Biomuta DOID:363 / uterine cancer [ icgc ]
S331 F331 Biomuta DOID:4159 / skin cancer [ cosmic ]